Platelet-Derived Growth Factor

Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.

Also Known As:

Networked: 2151 relevant articles (38 outcomes, 211 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ostman, Arne: 11 articles (06/2013 - 10/2002)
2.	Holland, Eric C: 10 articles (10/2012 - 07/2004)
3.	Kim, Hyeong-Reh Choi: 7 articles (01/2014 - 01/2003)
4.	Zhang, Wei: 7 articles (07/2012 - 05/2004)
5.	Buch, Shilpa: 7 articles (04/2011 - 04/2005)
6.	Heldin, Carl-Henrik: 7 articles (07/2009 - 10/2002)
7.	Ostendorf, Tammo: 6 articles (08/2015 - 03/2002)
8.	Eitner, Frank: 6 articles (08/2015 - 03/2002)
9.	Floege, Jürgen: 6 articles (08/2015 - 03/2002)
10.	Fuller, Gregory N: 6 articles (05/2015 - 04/2005)

Related Diseases

1.	Ulcer 07/01/2001 - "For example, recombinant platelet-derived growth factor, in addition to good ulcer care, has been shown to improve the number of ulcers that heal and healing times significantly compared with good ulcer care alone. " 10/01/2014 - "Efficacy of topical recombinant human platelet-derived growth factor for treatment of diabetic lower-extremity ulcers: Systematic review and meta-analysis." 02/01/2010 - "Efficacy of topical recombinant human platelet derived growth factor on wound healing in patients with chronic diabetic lower limb ulcers." 07/01/1995 - "Platelet-derived growth factor alone has shown promise in treating human chronic ulcers. " 10/01/2009 - "This study was designed to evaluate the acute safety and biologic feasibility of peri-ulcer injection of a replication-incompetent adenoviral construct expressing platelet-derived growth factor-beta (PDGF-beta). "
2.	Wounds and Injuries (Trauma) 05/01/2012 - "Recombinant human platelet-derived growth factor (rhPDGF) has been shown to improve healing in chronic wounds. " 10/01/2015 - "A bipedicle ischaemic rat skin flap model was used to study the effects of daily topical applications of platelet-derived growth factor (PDGF) on the healing of ischaemic wounds. " 11/01/2014 - "Studies have shown that local application of platelet-derived growth factor (PDGF) can be used for the treatment of acute and chronic wounds. " 07/01/2002 - "Topical platelet-derived growth factor enhances wound closure in the absence of wound contraction: an experimental and clinical study." 04/01/2002 - "Our preliminary study suggests that the topical application of 0.01% recombinant human platelet-derived growth factor gel accelerates healing of separated surgical wounds. "
3.	Neoplasms (Cancer) 06/01/2013 - "In this study, we describe a novel gene expression signature of platelet-derived growth factor (PDGF)-activated fibroblasts, which is able to identify breast cancers with a PDGF-stimulated fibroblast stroma and displays an independent and strong prognostic significance. " 06/01/2008 - "Studies have shown that platelet-derived growth factor (PDGF) signaling contributes to EMT, and more recently, PDGF-D has been shown to regulate cancer cell invasion and angiogenesis. " 12/15/2015 - "Platelet-derived growth factor (PDGF) released from cancer cell-stimulated platelets was determined by enzyme-linked immunosorbent assay (ELISA). " 07/01/2015 - "Platelet-derived growth factor (PDGF) signalling in cancer: rapidly emerging signalling landscape." 02/20/2015 - "Mutated KIT and platelet-derived growth factor alpha gene (PDGFRA) drive GI stromal tumor (GIST) oncogenesis, but the clinical significance of their single mutations is known incompletely. "
4.	Diabetic Foot 04/01/2009 - "Analysis of patient cost for recombinant human platelet-derived growth factor therapy as the first-line treatment of the insured patient with a diabetic foot ulcer." 11/01/2009 - "Treatment of nonhealing diabetic foot ulcers with a platelet-derived growth factor gene-activated matrix (GAM501): results of a phase 1/2 trial." 04/01/2015 - "Topical platelet derived growth factor does not appear to significantly improve healing of Wagner grade I diabetic foot ulcers that are treated by offloading with a short leg walking cast. " 04/01/2015 - "Topical platelet-derived growth factor vs placebo therapy of diabetic foot ulcers offloaded with windowed casts: a randomized, controlled trial." 04/01/2015 - "This study sought to compare the efficacy of topical platelet derived growth factor (Regranex, Smith and Nephew, London, UK) (test group) to placebo (control group) in treating diabetic foot ulcers. "
5.	Glioma (Gliomas) 05/01/2012 - "The efficacy of R-LM113 was assessed in a platelet-derived growth factor (PDGF)-induced infiltrative glioma model engineered to express HER2 and transplanted intracranially in adult NOD/SCID mice. " 11/15/1989 - "A clonal human glioma cell line, U-343 MGa 31L, which expresses the A-type but not the B-type receptor for platelet-derived growth factor (PDGF), was used in a functional study of the A-type receptor. " 03/15/2014 - "Orthotopic inoculation of NSCs with enhanced Id2 expression into brains of mice engineered to express platelet-derived growth factor in the central nervous system resulted in glioma. " 02/15/2014 - "Enhanced platelet-derived growth factor (PDGF) signaling in glioma drives its development and progression. " 01/16/2014 - "Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor -induced glioma in mice. "

Related Drugs and Biologics

1.	platelet-derived growth factor BB (becaplermin)
2.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
3.	imatinib (Gleevec)
4.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
5.	Transforming Growth Factor beta (TGF-beta)
6.	Epidermal Growth Factor (EGF)
7.	Fibroblast Growth Factors (Fibroblast Growth Factor)
8.	Protein-Tyrosine Kinases (Tyrosine Kinase)
9.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
10.	Intercellular Signaling Peptides and Proteins (Growth Factors)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Hyperbaric Oxygenation
3.	Amputation
4.	Hydrocolloid Bandages (Duoderm)
5.	Therapeutics