Arteriosclerosis

Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.

Also Known As:

Networked: 3176 relevant articles (68 outcomes, 301 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypertension (High Blood Pressure)
2.	Obesity
3.	Inflammation
4.	Infection
5.	Neoplasms (Cancer)

Experts

1.	Ensminger, Stephan M: 17 articles (01/2015 - 01/2002)
2.	Shimokawa, Hiroaki: 16 articles (05/2015 - 02/2002)
3.	Tellides, George: 16 articles (01/2014 - 03/2004)
4.	Xu, Qingbo: 15 articles (07/2015 - 01/2002)
5.	Spriewald, Bernd M: 14 articles (01/2015 - 01/2002)
6.	Wood, Kathryn J: 14 articles (01/2013 - 01/2002)
7.	Pober, Jordan S: 14 articles (11/2011 - 03/2004)
8.	Weyand, Michael: 11 articles (01/2015 - 01/2003)
9.	Lemström, Karl B: 10 articles (09/2010 - 02/2002)
10.	Koskinen, Petri K: 9 articles (03/2010 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Arteriosclerosis:

1.	CholesterolIBA 07/01/1989 - "The SEA strain of Japanese quail appears to be a practical model for the study of arteriosclerosis; fish oil reduces the severity of disease in these birds when fed a high cholesterol diet." 03/01/2005 - "Effect of cholesterol lowering and cardiovascular risk factors on the progression of aortoiliac arteriosclerosis: a quantitative cineangiography study." 04/01/1996 - "Our basis of the described theories of arteriosclerosis and cholesterol the multiple uneffective studies with reduction in levels of plasmalipids must be provided. " 07/01/1992 - "The aim of this controlled study was to give an answer to the question, whether cholesterol level in blood is as important for local cholesterol accumulation in the lens as it is for the mechanism of arteriosclerosis. " 01/01/1972 - "[Morphological and biochemical studies on the different development of cholesterol-induced aortic and coronary artery arteriosclerosis in rabbits]."
2.	proanthocyanidinIBA 11/01/2012 - "Grape seed proanthocyanidin extract (GSPE) has been reported to be effective in treating arteriosclerosis, while little is known about its effect on systolic blood pressure and vascular remodeling. " 02/01/2010 - "Grape seed proanthocyanidin extracts (GSPE) have been reported to be effective in treating arteriosclerosis, while little is known about the functional protein changes. " 06/01/2009 - "Grape seed proanthocyanidin extracts (GSPEs) have been reported to be effective in treating arteriosclerosis, while little is known about therapeutic agents against diabetic macrovascular complications. "
3.	Lipoproteins (Lipoprotein)IBA 01/01/1988 - "Endurance training induces alterations in the lipoprotein metabolism which could be useful for protection against arteriosclerosis. " 01/01/2010 - "Recent studies have demonstrated that not only plasma low-density lipoprotein (LDL) levels, but also the number of small dense LDL particles are involved in the development of arteriosclerosis. " 04/01/1957 - "[Diagnosis & evaluation of therapeutic measures in arteriosclerosis; paper electrophoretic determination of lipoproteins for the study of fat metabolic disorders & determination of pulse wave rate as a measure of vascular elasticity]." 04/01/2012 - "SdLDL is a lipoprotein subclass that causes arteriosclerosis with a much higher risk than large LDL. " 06/01/2008 - "Oxidized to non-oxidized lipoprotein ratios are associated with arteriosclerosis and the metabolic syndrome in diabetic patients."
4.	Biological Markers (Surrogate Marker)IBA 02/01/2013 - "Research on age-related traits continues with studies on arteriosclerosis development, early biomarkers in mild cognitive impairment, and the relation between lifestyle habits and mutagen sensitivity. " 12/02/2015 - "This result may suggest that worsening of the periodontal condition assessed by GCF biomarkers is not a major potential risk factor for arteriosclerosis. " 12/02/2015 - " correlation between the GCF biomarkers and the severity of arteriosclerosis was detected. " 05/01/2015 - "The ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) are surrogate markers of arteriosclerosis. " 02/01/2013 - "Arterial stiffness has been known to be a surrogate marker of arteriosclerosis, and also of vascular function. "
5.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 09/24/1996 - "Whether low-dose aspirin is equally effective for reducing progression of arteriosclerosis in the cerebrovascular and in the peripheral vessels is questionable. " 03/01/2010 - "Arteriosclerosis in the 4 mg/kg/day aspirin group was decreased significantly compared with the placebo group, but not in the 40 mg/kg/day aspirin group. " 08/01/2009 - "Generalized estimating equations were used to assess whether plasma levels of haemostatic markers were associated with measures of arteriosclerosis, after adjustment for conventional risk factors and medication (statin, aspirin and oestrogen) use. " 07/01/1985 - "We concluded that: 1) aspirin markedly reduced the microscopic and macroscopic arteriosclerosis in Groups B and C; 2) aspirin in Group B not only arrested further development but also permitted resolution of arteriosclerosis while the arteries were still being injured." 11/01/1988 - "[Evaluation of the effect of polopirin S on platelet adhesiveness in chronic peripheral circulatory failure in arteriosclerosis]."
6.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 03/27/2000 - "Inducible nitric oxide synthase (iNOS) is up-regulated in rejecting allografts and is protective against allograft arteriosclerosis; it suppresses neointimal smooth muscle cell accumulation and inhibits adhesion of platelets and leukocytes to the endothelium. " 11/06/2001 - "Inducible nitric oxide synthase (iNOS, or NOS2) reduces the severity of accelerated graft arteriosclerosis (AGA) in transplanted organs, although the precise mechanism is unclear. " 09/18/2001 - "Inducible nitric oxide synthase (iNOS) is expressed and is functionally active in the presence of transplant arteriosclerosis. " 12/01/1999 - "Role of inducible nitric oxide synthase in transplant arteriosclerosis." 10/15/1997 - "Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis."
7.	pioglitazone (Actos)FDA Link 01/01/2006 - "Pioglitazone was also effective in reducing some measures of cardiovascular risk and arteriosclerosis. " 01/01/2006 - "Pioglitazone was also effective in reducing some measures of cardiovascular risk and arteriosclerosis. " 08/01/2005 - "Pioglitazone improves aortic wall elasticity in a rat model of elastocalcinotic arteriosclerosis." 05/01/2005 - "Effect of pioglitazone on arteriosclerosis in comparison with that of glibenclamide." 11/01/2002 - "We examined the effects of pioglitazone (a PPARgamma ligand) in this rat model to determine whether PPARgamma activation with pioglitazone inhibits arteriosclerosis by its indirect effects on metabolic conditions or by direct effects on the cells participating to the pathogenesis of arteriosclerosis. "
8.	rho-Associated KinasesIBA 01/01/2013 - "In a series of experimental and clinical studies, it has been demonstrated that Rho-kinase-mediated pathway plays an important role in various cellular functions not only in vascular smooth muscle hyperconstriction but also in actin cytoskeleton organization, cell adhesion and motility, cytokinesis, and gene expressions, all of which may be involved in the pathogenesis of arteriosclerosis. " 04/01/2007 - "In a series of experimental and clinical studies, we have demonstrated that Rho-kinase-mediated pathway plays an important role in various cellular functions, not only in vascular smooth muscle hyperconstriction but also in actin cytoskeleton organization, cell adhesion and motility, cytokinesis, and gene expression, all of which may be involved in the pathogenesis of arteriosclerosis. " 08/01/2004 - "Recent studies have demonstrated that upregulated Rho-kinase plays an important role in the pathogenesis of arteriosclerosis and vasospasm in both animals and humans. " 08/01/2004 - "Since inflammatory mechanisms have been implicated in the pathogenesis of arteriosclerosis and vasospasm, we examined whether inflammatory stimuli upregulate Rho-kinase in vitro and in vivo. " 05/01/2002 - "The Rho/Rho-kinase pathway is involved in the pathogenesis of hypertension, vasospasm and arteriosclerosis, and is a potent target of new therapies for these diseases."
9.	Heparin (Liquaemin)FDA LinkGeneric 06/01/1954 - "[Action of heparin in arteriosclerosis: clinical and experimental study]." 09/01/2005 - "Exercise after heparin administration: new therapeutic program for patients with-option arteriosclerosis oblitrans." 01/01/1980 - "Continuous heparin anticoagulation in patients with arteriosclerosis and arterial emboli." 08/01/1976 - "[Effect of heparin electrophoresis on myocardial function in patients with arteriosclerosis]." 09/01/1967 - "[On the interrelationship between the level of free heparin and blood basophil count in experimental arteriosclerosis]."
10.	Glucose (Dextrose)FDA LinkGeneric 05/10/1974 - "[Studies on the disturbance of glucose and lipid metabolism in arteriosclerosis (author's transl)]." 08/01/2015 - "Glucose-lowering therapy must be compatible with immunosuppressant agents, reduced glomerular filtration rate (GFR) and severe arteriosclerosis. " 08/01/2013 - "This finding suggests that circulating OC and ucOC are not only related to glucose or fat metabolism but also to arteriosclerosis. " 04/01/2011 - "All subjects were received 75g oral glucose tolerance test (OGTT) to evaluate glucose metabolic level, and brachial-ankle pulse wave velocity (baPWV) examination to evaluate arteriosclerosis. " 02/01/2007 - "Visceral, hormonal and neuroendocrine changes after the sixth decade of life result from slowing down and alteration in metabolic, hormonal, protein, lipid and glucose turnover, progressive receptor insensitivity, degenerative processes--primarily arteriosclerosis--of the endocrine and non endocrine tissues. "

Therapies and Procedures

1.	Transplants (Transplant) 01/27/2008 - "We found that an anti-angiogenic therapy (ABT-510 nonapeptide), devoid of direct immunomodulatory properties, dramatically reduced adventitial angiogenesis by 66% (P<0.0001) in the rat aortic interposition model of graft arteriosclerosis. " 11/01/1998 - "Although these grafts have become more technically feasible and have shown benefits, more follow-up data are needed to determine the long-term patency, freedom from arteriosclerosis, and efficacy of alternative conduits." 09/01/2006 - "The correlation between MMF and A20 provide an explanation for the mechanism by which MMF ameliorates transplant arteriosclerosis in an experimental animal model of chronic rejection." 01/07/2014 - "The aim of this study was to determine the role of suppressor of cytokine signaling 1 (SOCS1) in graft arteriosclerosis (GA). " 03/01/2013 - "The aim of this study was to explore underlying mechanisms of transplant arteriosclerosis (TA) based on intimal thickening that involve activation of vascular smooth muscle cells (VSMCs) and angiogenesis. "
2.	Homologous Transplantation (Allograft) 03/01/2007 - "Fish oil ameliorates the allograft arteriosclerosis of intestine on rats." 12/01/2008 - "This study investigated regulation of the Notch pathway on cardiac allograft arteriosclerosis and further examined its implication in EC dysfunction. " 02/20/2002 - "Previous studies have suggested an independent role of ET-1 and PDGF in the development of cardiac allograft arteriosclerosis (i.e., chronic rejection). " 06/27/2001 - "Studies of cardiac allograft arteriosclerosis, i.e., chronic rejection, have largely focused on mononuclear inflammatory cell infiltrates in the vascular wall and periphery of the occluded vessels. " 06/01/1996 - "Chronic allograft arteriosclerosis: contributing factors and molecular mechanisms in the light of experimental studies."
3.	Transplantation (Transplant Recipients) 09/01/1996 - "Isolated coronary artery transplantation in pigs: a new model to study transplantation arteriosclerosis and humoral rejection." 11/01/1982 - "Arteriosclerosis in normal and von Willebrand pigs: long-term prospective study and aortic transplantation study." 03/01/2015 - "Increased arterial stiffness as assessed by PWV predicts CVE in renal transplant recipients and may be regarded as a footprint of accelerated arteriosclerosis for those patients." 07/01/2010 - "We hypothesized that these IFN-gamma-conditioned T cells (Tcon) would reduce transplantation-associated arteriosclerosis. " 08/01/2009 - "Transplantation of kidneys from donor with arteriosclerosis seen on pre-implantation biopsy has not been well studied. "
4.	Heart Transplantation (Grafting, Heart) 10/01/2005 - "Thus, CAVI may be useful in the diagnosis of arteriosclerosis after heart transplantation." 04/01/1994 - "Accelerated arteriosclerosis is now the major long-term complication of heart transplantation. " 05/01/1993 - "Accelerated arteriosclerosis is the major long-term complication of cardiac transplantation. " 10/01/1990 - "Accelerated arteriosclerosis has emerged as a major life-threatening complication in long-term survivors of heart transplantation. " 03/01/1989 - "The development of arteriosclerosis is the most serious and common complication in long-term survivors of cardiac transplantation. "
5.	Kidney Transplantation 08/01/2009 - "Single versus dual renal transplantation from donors with significant arteriosclerosis on pre-implant biopsy." 01/01/2009 - "Color Doppler sonography indices, such as resistive index (RI) and pulsatility index (PI), can predict arteriosclerosis of internal renal vessels after kidney transplantation. " 03/01/2007 - "Severe arteriosclerosis is usually not a contraindication for kidney transplantation. " 01/01/2004 - "[Renal transplantation and arteriosclerosis in the transplanted organ]." 12/01/1994 - "Re: Reassessment of the value of post-vascularization biopsy performed at renal transplantation: the effects of arteriosclerosis."