Cardioprotective effect of Malva sylvestris L. in myocardial ischemic/reprefused rats.

Abstract

PURPOSE:

The present investigation evaluated the cardioprotective effect of Malva sylvestris L. (MS) on myocardial ischemic/reperfusion (MI/R) in rats.

METHODS:

All animals were divided into four groups: the sham operated group, ischemia/reperfusion group (MI/R), and the MS (250 and 500mg/kg) treated groups, who received MS 250 and 500mg/kg intragastrically for 15 consecutive days, respectively. At the end of the protocol, concentrations of aspartate transaminase (AST), creatine kinase-MB fraction (CK-MB) and lactate dehydrogenase (LDH) were estimated in serum and the concentrations of other parameters, such as C-reactive protein, macrophage inflammatory protein 1 alpha (MIP-1α), and nitric oxide (NO) were also estimated in the blood. Tissue homogenate concentrations of inflammatory cytokines, such as tumour necrosis factor-α (TNF-α), interlukin-1β (IL-1β), IL-10 and IL-6 as well as oxidative stress parameters, such as lipid peroxidation, catalase, and superoxide dismutase were estimated in MI/R rats.

RESULT:

Significant decreases (p<0.01) in AST, LDH, and CK-MB levels were observed in the MS-treated group compared with those in the MI/R group. C-reactive protein and MIP-1α levels decreased in the MS-treated group compared with those in the MI/R group. Plasma NO level was significantly enhanced in the MS-treated group than in the MI/R group. Moreover, treatment with MS significantly reduced TNF-α, IL-1β, and IL-6 levels and increased IL-10 levels in the MS group compared with the MI/R group. Treatment with MS also attenuated the altered oxidative stress parameters in MI/R rats.

CONCLUSION:

The present results indicate the cardioprotective effects of MS of reducing oxidative stress and the inflammatory response in MI/R rats.

• Authors: Hanheng Zuo, Yinping Li, Yinghua Cui, Yi An
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 95 Pg. 679-684 (Nov 2017) ISSN: 1950-6007 [Electronic] France
• PMID: 28886527 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Chemical References

• Biomarkers
• Cardiotonic Agents
• Chemokine CCL3
• Inflammation Mediators
• Plant Extracts
• Nitric Oxide
• C-Reactive Protein

Topics

• Animals
• Biomarkers (metabolism)
• C-Reactive Protein (metabolism)
• Cardiotonic Agents (pharmacology, therapeutic use)
• Chemokine CCL3
• Electrocardiography
• Inflammation Mediators (metabolism)
• Male
• Malva
• Myocardial Reperfusion Injury (blood, diagnostic imaging, drug therapy, pathology)
• Nitric Oxide (blood, metabolism)
• Oxidative Stress (drug effects)
• Plant Extracts (pharmacology, therapeutic use)
• Rats, Sprague-Dawley
• ST Elevation Myocardial Infarction (blood, diagnostic imaging, drug therapy)