Abstract |
This study evaluated whether long-term supplementation with dietary yerba mate has beneficial effects on adiposity and its related metabolic dysfunctions in diet-induced obese mice. C57BL/6J mice were randomly divided into two groups and fed their respective experimental diets for 16 weeks as follows: (1) control group fed with high-fat diet (HFD) and (2) mate group fed with HFD plus yerba mate. Dietary yerba mate increased energy expenditure and thermogenic gene mRNA expression in white adipose tissue (WAT) and decreased fatty acid synthase (FAS) mRNA expression in WAT, which may be linked to observed decreases in body weight, WAT weight, epididymal adipocyte size, and plasma leptin level. Yerba mate also decreased levels of plasma lipids ( free fatty acids, triglycerides, and total cholesterol) and liver aminotransferase enzymes, as well as the accumulation of hepatic lipid droplets and lipid content by inhibiting the activities of hepatic lipogenic enzymes, such as FAS and phosphatidate phosphohydrolase, and increasing fecal lipid excretion. Moreover, yerba mate decreased the levels of plasma insulin as well as the homeostasis model assessment of insulin resistance, and improved glucose tolerance. Circulating levels of gastric inhibitory polypeptide and resistin were also decreased in the mate group. These findings suggest that long-term supplementation of dietary yerba mate may be beneficial for improving diet-induced adiposity, insulin resistance, dyslipidemia, and hepatic steatosis.
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Authors | Myung-Sook Choi, Hyo Jin Park, Sang Ryong Kim, Do Yeon Kim, Un Ju Jung |
Journal | Journal of medicinal food
(J Med Food)
Vol. 20
Issue 12
Pg. 1168-1175
(Dec 2017)
ISSN: 1557-7600 [Electronic] United States |
PMID | 28872427
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Plant Extracts
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Topics |
- Adipose Tissue, White
(drug effects, metabolism)
- Animals
- Blood Glucose
(metabolism)
- Body Weight
(drug effects)
- Diet, High-Fat
(adverse effects)
- Dietary Supplements
(analysis)
- Energy Metabolism
(drug effects)
- Humans
- Ilex paraguariensis
(chemistry)
- Lipid Metabolism
(drug effects)
- Male
- Metabolic Diseases
(drug therapy, metabolism, physiopathology)
- Mice
- Mice, Inbred C57BL
- Mice, Obese
- Obesity
(drug therapy, etiology, metabolism, physiopathology)
- Plant Extracts
(administration & dosage)
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