Abstract | CONTEXT:
Lactoferrin (Lf) is an important protein found on mucosal surfaces, within neutrophils and various cells, and in biological fluids. It displays multiple functions, including iron-binding as well as antimicrobial, immunomodulatory and anti-inflammatory activities. Although Lf ingestion has been suggested to cause adiposity reduction in murine models and humans, its relationship with insulin resistance (IR) has not been studied thoroughly. OBJECTIVE: METHODS: RESULTS: Although body mass index (BMI) and total body fat mass were negatively associated with Lf, IR (assessed by the HOMA-IR index) was positively and independently associated with plasma Lf concentrations of the first cohort of lean to moderately obese women. These observations were validated in the second cohort in view of the positive correlation between plasma Lf concentrations and the HOMA-IR index, but without a significant association with the body mass index (BMI) of severely obese subjects. In subsamples of severely obese subjects matched for sex, age and BMI, but with either relatively low (1.89 ± 0.73) or high (13.77 ± 8.81) IR states (according to HOMA-IR), higher plasma Lf levels were noted in insulin-resistant vs insulin-sensitive subjects (P<0.05). Finally, Lf levels were significantly higher in lean to moderately obese women than in severely obese subjects (P<0.05). CONCLUSION: Our findings revealed that plasma Lf levels are strongly associated with IR independently of total adiposity, which suggests an intriguing Lf regulation mechanism in conditions of obesity and IR.
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Authors | Sylvain Mayeur, Alain Veilleux, Yves Pouliot, Benoît Lamarche, Jean-François Beaulieu, Frédéric S Hould, Denis Richard, André Tchernof, Emile Levy |
Journal | PloS one
(PLoS One)
Vol. 11
Issue 11
Pg. e0166138
( 2016)
ISSN: 1932-6203 [Electronic] United States |
PMID | 27902700
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Blood Glucose
- LTF protein, human
- Lipids
- Lipoproteins
- Lactoferrin
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Topics |
- Adiposity
(physiology)
- Adult
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Cohort Studies
- Female
- Humans
- Insulin Resistance
- Lactoferrin
(blood)
- Lipids
(blood)
- Lipoproteins
(blood)
- Male
- Middle Aged
- Obesity
(physiopathology)
- Thinness
(physiopathology)
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