Lactoferrin

An iron-binding protein in plasma and secretions (milk, mucus, bile), secreted by leukocytes. It is an important component of GRANULOCYTES. It is bacteriostatic, working by depriving bacteria of iron essential for growth.

Also Known As:

Networked: 1625 relevant articles (109 outcomes, 268 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kruzel, Marian L: 24 articles (07/2015 - 03/2002)
2.	Actor, Jeffrey K: 19 articles (07/2015 - 03/2002)
3.	Valenti, Piera: 18 articles (10/2014 - 01/2002)
4.	Yamauchi, Koji: 17 articles (11/2014 - 03/2002)
5.	Hwang, Shen-An: 16 articles (07/2015 - 03/2002)
6.	Superti, Fabiana: 15 articles (02/2015 - 02/2002)
7.	Kanwar, Jagat R: 12 articles (12/2015 - 03/2008)
8.	Kanwar, Rupinder K: 12 articles (12/2015 - 03/2008)
9.	Iigo, Masaaki: 12 articles (07/2015 - 06/2002)
10.	Wakabayashi, Hiroyuki: 12 articles (11/2014 - 10/2002)

Related Diseases

1.	Infection 12/01/2004 - "The lactoferrin-derived peptide hLF(1-11), but not its control peptide, was highly effective against five multidrug-resistant Acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in an experimental infection in mice (2 to 3 log reduction). " 12/01/2004 - "The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii." 01/01/2011 - "The capability of lactoferrin to exert a potent antiviral activity, through its binding to host cells and/or viral particles, and its nuclear localization strengthens the idea that lactoferrin is an important brick in the mucosal wall, effective against viral attacks and it could be usefully applied as novel strategy for treatment of viral infections." 08/01/2008 - "Lactoferrin is considered an important first line defense protein involved in protection against various microbial infections. " 01/01/2008 - "Application of bovine lactoferrin (LF), 10 mg i.v., 24 h before infection, was also very effective in reducing CFU numbers. "
2.	Neoplasms (Cancer) 12/01/2015 - "This is the first ever attempt to combine anti-cancer therapeutic effects of emerging anticancer biodrug bovine lactoferrin (bLf), and multimodal imaging efficacy of Fe3O4 nanoparticles (NPs) together, as a saturated Fe3O4-bLf. " 09/01/2003 - "Lactoferrin proved effective in reducing malignant tumor growth in a murine model. " 03/10/2003 - "Consistent downregulation of human lactoferrin gene, in the common eliminated region 1 on 3p21.3, following tumor growth in severe combined immunodeficient (SCID) mice." 12/01/2014 - "Several studies suggest that exogenous treatment with lactoferrin and its derivatives can efficiently inhibit the growth of tumors and reduce susceptibility to cancer. " 07/01/2010 - "In this study we found lactoferrin to inhibit proliferation of the human epithelial cancer cell line HeLa. "
3.	Sepsis (Septicemia) 01/01/2011 - "Oral lactoferrin prophylaxis reduces the incidence of late-onset sepsis in infants weighing less than 1500 g and most effective in infants weighing less than 1000 g. " 01/01/2010 - "Oral lactoferrin prophylaxis reduces the incidence of late-onset sepsis in infants weighing less than 1500 g and most effective in infants weighing less than 1000 g. " 01/01/2011 - "In the group supplemented with oral lactoferrin and Lactobacillus rhamnosus, infants weighing less than 1000 g had a significant reduction in late-onset sepsis, a result not seen in infants fed maternal milk exclusively.Prophylaxis" 01/01/2011 - "A statistically significant reduction in late-onset sepsis was observed in the groups that received either lactoferrin alone (RR 0.34, 95% CI 0.17 to 0.70) or in combination with Lactobacillus rhamnosus GG (RR 0.27, 95% CI 0.12 to 0.60).In subgroup analyses, infants weighing less than 1000 g and those fed exclusively on maternal milk had a significant reduction in late-onset sepsis after oral lactoferrin supplementation alone. " 01/01/2010 - "In the group supplemented with oral lactoferrin and Lactobacillus rhamnosus, infants weighing less than 1000 g had a significant reduction in late-onset sepsis, but not exclusively maternal milk fed infants.Prophylaxis"
4.	Inflammation 01/28/2014 - "A preterm pig model was used to investigate the protective effects of enteral bovine lactoferrin (bLF) against NEC development and inflammation. " 10/01/2015 - "LFP-20, a porcine lactoferrin peptide, ameliorates LPS-induced inflammation via the MyD88/NF-κB and MyD88/MAPK signaling pathways." 08/01/1998 - "Circulating lactoferrin is cleared in the liver, but little is known about the implication of lactoferrin in hepatic inflammation. " 01/01/2015 - "Aim of the study is to compare fecal lactoferrin (FL) as biomarker of intestinal inflammation to CRP in pediatric patients with new-onset IBD. " 09/01/2014 - "The aim of this study was to evaluate lactoferrin quantification as a sensitive and objective method of detecting the degree of periodontal inflammation, oxidative stress and to monitor the effects of periodontal therapy. "
5.	Mastitis 11/01/2006 - "The aim of the study was to investigate the concentrations in milk and protective effects of bovine and recombinant human lactoferrin in experimental Escherichia coli mastitis. " 04/01/2015 - "The findings indicate potential scope for incorporation of lactoferrin gene in selection and breeding of Murrah buffaloes for improved genetic resistance to mastitis. " 08/01/2004 - "The efficacy of bovine lactoferrin in the treatment of cows with experimentally induced Escherichia coli mastitis." 04/01/2015 - "The present study was undertaken with the objectives to identify allelic variants in exons 7 and 12 of lactoferrin gene and to analyze association between its genetic variants and incidence of clinical mastitis in Murrah buffalo. " 01/01/2015 - "Results from this study indicated the probable role played by Lactoferrin promoter to serve as candidate gene for mastitis susceptibility among indigenous and crossbred milch cattle. "

Related Drugs and Biologics

1.	Iron
2.	Peroxidase (Myeloperoxidase)
3.	Muramidase (Lysozyme)
4.	Leukocyte L1 Antigen Complex (Calgranulin)
5.	Carrier Proteins (Binding Protein)
6.	BCG Vaccine
7.	Anti-Bacterial Agents (Antibiotics)
8.	Antigens
9.	Lactoferrin
10.	Penicillins (Penicillin)

Related Therapies and Procedures

1.	Oral Administration
2.	Drug Therapy (Chemotherapy)
3.	Intraperitoneal Injections
4.	Fluid Therapy (Oral Rehydration Therapy)
5.	Colectomy