Abstract | BACKGROUND: OBJECTIVE: RESULTS: Recent findings in animal models and humans show that polyphenols may have a role in regulating neurotrophins levels, in particular nerve growth factor ( NGF) and brainderived neurotrophic factor ( BDNF), suggesting that polyphenols may also induce their protective effects through the potentiation of neurotrophins action. NGF and BDNF, primarily known as biological mediators stimulating neuron growth, proliferation, survival and differentiation are recently studied also as metabotrophic factors, acting on glucose and energy metabolism, pancreatic beta cells and cardiovascular homeostasis. CONCLUSION: In this context, a better understanding of the effects of polyphenols on neurotrophins and their receptors (TrkA, TrkB, p75NTR) could certainly generate interest for drug discovery and also for the potential dietary prevention of several neurological and cardiometabolic diseases.
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Authors | Valentina Carito, Mauro Ceccanti, Luigi Tarani, Giampiero Ferraguti, George N Chaldakov, Marco Fiore |
Journal | Current medicinal chemistry
(Curr Med Chem)
Vol. 23
Issue 28
Pg. 3189-3197
( 2016)
ISSN: 1875-533X [Electronic] United Arab Emirates |
PMID | 27356540
(Publication Type: Journal Article, Review)
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Chemical References |
- Nerve Growth Factors
- Neuroprotective Agents
- Polyphenols
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Topics |
- Brain
(drug effects, metabolism)
- Humans
- Nerve Growth Factors
(metabolism)
- Neurodegenerative Diseases
(drug therapy, metabolism, pathology)
- Neuroprotective Agents
(chemistry, pharmacology, therapeutic use)
- Olea
(chemistry, metabolism)
- Oxidative Stress
(drug effects)
- Polyphenols
(chemistry, pharmacology, therapeutic use)
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