Brain-Derived Neurotrophic Factor (BDNF)

A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)

Also Known As:

Networked: 4612 relevant articles (205 outcomes, 983 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tsai, Shih-Jen: 35 articles (07/2015 - 01/2003)
2.	Quevedo, João: 33 articles (09/2015 - 06/2006)
3.	Kapczinski, Flávio: 32 articles (09/2015 - 06/2006)
4.	Hashimoto, Kenji: 30 articles (02/2015 - 07/2003)
5.	Nakamura, Jun: 25 articles (08/2015 - 06/2006)
6.	Hellweg, Rainer: 25 articles (06/2015 - 05/2003)
7.	Yoshimura, Reiji: 24 articles (08/2015 - 06/2006)
8.	Hu, Yu: 24 articles (05/2015 - 02/2005)
9.	Zhang, Xiang Yang: 23 articles (01/2016 - 05/2005)
10.	Kennedy, James L: 22 articles (11/2015 - 09/2002)

Related Diseases

1.	Stroke (Strokes) 01/01/2013 - "Taken together, these results provide strong evidence that human neural stem cells (F3.BDNF) are effective in treating stroke animal models." 07/01/2007 - "Daily intravenous bolus applications of BDNF during the first 5 days after stroke resulted in significantly improved sensorimotor scores up to 6 weeks. " 05/06/2015 - "BDNF genotype influence the efficacy of rTMS in stroke patients." 01/01/2012 - "In conclusion, exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in the hippocampus of stroke-prone hypertensive rats." 01/01/2012 - "Exercise training for 28 days improved cognitive decline determined by Morris water maze test via up-regulation of BDNF in the hippocampus of stroke-prone spontaneously hypertensive rats, whereas calorie restriction for 28 days did not. "
2.	Brain Injuries (Brain Injury) 11/01/2000 - "These findings indicate that unilateral H-I brain injury in a neonatal rodent model is associated with cognitive deficits, and that BDNF pretreatment is protective against both brain injury and spatial memory impairment." 09/08/2009 - "Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation." 08/19/2014 - "Therefore, the aim of this study was to investigate the neuroprotective mechanisms of HO-1 against ischemic brain injury induced by cerebral I/R and to explore whether the BDNF-TrkB-PI3K/Akt signaling pathway contributed to the protection provided by HO-1. " 02/01/2013 - "These studies demonstrate that by increasing the brain concentration of BDNF, intraventricularly transplanted MSCs-BDNF might play an important role in the treatment of traumatic brain injury and might be an optional therapeutic strategy." 02/01/2013 - "Further studies showed that treatment of traumatic brain injury with MSCs-BDNF could attenuate neuronal injury as measurement of biological behavior assessment. "
3.	Brain Ischemia (Cerebral Ischemia) 11/01/2012 - "BDNF antibody block leads to a significant reduction of MEK expression in endothelia cells of lung tissue in the rats with brain ischemia." 01/01/2015 - "In a mouse model of focal cerebral ischemia, we observed higher expression of mature BDNF and phosphorylation of CREB in the hippocampus and further confirmed improved spatial memory by treatment with PMC-12. " 01/01/2013 - "Pretreatment with EA increased the production of BDNF and SDF-1α, which elicited protective effects against focal cerebral ischemia. " 01/01/2011 - "The current study used a rat brain ischemia model to investigate the effects of voluntary wheel running, involuntary muscle movement caused by functional electrical stimulation (FES), and forced treadmill exercise on motor recovery and brain BDNF changes. " 03/01/2007 - "This greatly facilitates the next step in the study, such as the long period of therapeutic observation of cerebral ischemia with Bdnf gene-modified rMSCs."
4.	Alzheimer Disease (Alzheimer's Disease) 02/01/2015 - "Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease." 01/01/2015 - "Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by aβ1-42." 07/01/2013 - "In the present study, 1H-MRS was used to evaluate the therapeutic effects of bilateral intraventricular BDNF infusion into Alzheimer's disease APP/PS1 double transgenic mice. " 02/01/2013 - "Brain-derived neurotrophic factor gene variants and Alzheimer disease: an association study in an Alzheimer disease Italian population." 09/01/2012 - "Studies have reported altered BDNF serum concentrations in patients with Alzheimer's disease (AD). "
5.	Schizophrenia (Dementia Praecox) 03/01/2006 - "After reviewing principles important for the selection of genes, neuroimaging techniques, and subjects, we describe how imaging-genetics investigations have helped clarify the contribution of five candidate genes (COMT, GRM3, G72, DISC1, and BDNF) to cognitive deficits in schizophrenia. " 12/15/2014 - "This study did not find a significant relationship between serum BDNF and remission in patients with schizophrenia. " 03/01/2011 - "Although peripheral BDNF levels hold promise for providing new perspectives for the development of novel therapeutic strategies for the treatment of schizophrenia, additional studies including efforts to prove its potential as a biomarker are warranted." 07/01/2015 - "The results indicate AE is effective in enhancing neurocognitive functioning in people with schizophrenia and provide preliminary support for the impact of AE-related BDNF up-regulation on neurocognition in this population. " 12/15/2014 - "In this study, we seek to examine if serum BDNF level is associated with remission status in a sample of Chinese patients with schizophrenia. "

Related Drugs and Biologics

1.	Brain-Derived Neurotrophic Factor (BDNF)
2.	Nerve Growth Factor (NGF)
3.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)
4.	Nerve Growth Factors (Neurotrophins)
5.	Messenger RNA (mRNA)
6.	Phosphotransferases (Kinase)
7.	Retinaldehyde (Retinal)
8.	Minocycline (Cyclops)
9.	Amyloid (Amyloid Fibrils)
10.	Leptin

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Aftercare (After-Treatment)
3.	Drug Therapy (Chemotherapy)
4.	Axotomy
5.	Electroacupuncture