Chlorella Protein Hydrolysate Attenuates Glucose Metabolic Disorder and Fatty Liver in High-fat Diet-induced Obese Mice.

Abstract

Chlorella (Parachlorella beijerinckii) powder is reported to show a preventive effect against metabolic syndromes such as arteriosclerosis, hyperlipidemia, and hypertension. Approximately 60% of the chlorella content is protein. In order to understand the role of chlorella protein, we prepared a chlorella protein hydrolysate (CPH) by protease treatment. Male C57BL/6 mice were divided into three groups: a normal diet group, high-fat diet (HFD) group, and high-fat diet supplemented with CPH (HFD+CPH) group. The CPH administration improved glucose intolerance, insulin sensitivity, and adipose tissue hypertrophy in the high-fat diet-fed mice. In addition, the HFD+CPH group had significantly decreased liver total cholesterol and triglyceride levels compared with those in the HFD group. Furthermore, the HFD+CPH group had a decreased level of monocyte chemotactic protein-1 (MCP-1) in serum and a lower MCP-1 mRNA expression level in adipose tissue compared with the HFD group. The present study suggests that chlorella protein hydrolysate can prevent a high-fat diet-induced glucose disorder and fatty liver by inhibiting adipocyte hypertrophy and reducing the MCP-1 protein and gene expression.

• Authors: Naoto Noguchi, Teruyoshi Yanagita, Shaikh Mizanoor Rahman, Yotaro Ando
• Journal: Journal of oleo science (J Oleo Sci) Vol. 65 Issue 7 Pg. 613-20 (Jul 01 2016) ISSN: 1347-3352 [Electronic] Japan
• PMID: 27321121 (Publication Type: Journal Article)

Chemical References

• Protein Hydrolysates

Topics

• Animals
• Chlorella (chemistry, metabolism)
• Diet, High-Fat (adverse effects)
• Fatty Liver (drug therapy, metabolism)
• Glucose Metabolism Disorders (drug therapy, metabolism)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Obese
• Obesity (etiology, metabolism)
• Protein Hydrolysates (chemistry, pharmacology)