MicroRNAs in oral lichen planus and potential miRNA-mRNA pathogenesis with essential cytokines: a review.

Abstract

Oral lichen planus (OLP) is a potentially premalignant condition with unknown pathogenesis. Immune and inflammatory factors are thought to play important roles in the development of OLP, and cytokines, such as interferon (IFN)-γ and tumor necrosis factor (TNF)-α, can act as critical players in the immunopathogenesis of OLP. MicroRNAs (miRNAs) are closely correlated with cytokines in various inflammation-related diseases. In patients with OLP, miRNA-146a and miRNA-155 are increased in peripheral blood mononuclear cells, and numerous miRNAs have been shown to exhibit altered expression profiles in lesions. Although the microRNA-messenger RNA (miRNA-mRNA) network is thought to be involved in the development of OLP, in-depth studies are lacking. Here, we summarize current data on the mechanisms of action of miRNAs regulating typical cytokines in OLP, including interleukin (IL)-10, IL-17, IL-22, IFN-γ, and TNF-α, to study the genetic basis of the pathogenesis of OLP and to provide prospects of therapy.

• Authors: Hui Ma, Yuanqin Wu, Huamei Yang, Jiajia Liu, Hongxia Dan, Xin Zeng, Yu Zhou, Lu Jiang, Qianming Chen
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 122 Issue 2 Pg. 164-73 (Aug 2016) ISSN: 2212-4411 [Electronic] United States
• PMID: 27282956 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Cytokines
• MicroRNAs

Topics

• Cytokines (genetics)
• Humans
• Lichen Planus, Oral (genetics, pathology, prevention & control)
• MicroRNAs (genetics)
• Precancerous Conditions (genetics, pathology, prevention & control)