Abstract | OBJECTIVES: METHODS: In a prospective controlled cross-sectional study, serum concentrations of IL-6, IL-8, IL-10, TNF-α, thiobarbituric acid reactive substances ( TBARS), protein carbonyl and BDNF were measured in 69 FM patients and 61 healthy controls (all women). In the FM group, the Fibromyalgia Impact Questionnaire (FIQ), the Beck Depression Inventory (BDI) and the Hamilton Depression Rating Scale (HDRS) were applied. Mann Whitney's and Spearman correlation tests were used for statistical analysis. RESULTS: The FM patients demonstrated a significant impact of the disease on quality of life (FIQ 70.2±17.8) and most of them had depression at some level (82.6% and 87.0% as assessed by BDI and HDRS, respectively). Most biomarkers (IL-6, IL-8, TNF-α, TBARS and protein carbonyl) and BDNF did not differ significantly between patients and controls, but the IL-10 levels were higher in FM patients (adjusted p=0.041). Among FM patients, there was no correlation of HDRS, FIQ, and BDI scores with any biomarker tested here. CONCLUSION: We observed no significant differences in biomarkers between FM patients and controls, except for higher levels of IL-10 (an anti-inflammatory cytokine) in patients. The levels of biomarkers were not correlated with parameters of disease and depression severity.
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Authors | Aline Ranzolin, Angela Luzia Branco Pinto Duarte, Markus Bredemeier, Cláudio Antônio da Costa Neto, Bruna Maria Ascoli, Bianca Wollenhaupt-Aguiar, Flávio Kapczinski, Ricardo Machado Xavier |
Journal | Cytokine
(Cytokine)
Vol. 84
Pg. 25-8
(08 2016)
ISSN: 1096-0023 [Electronic] England |
PMID | 27209553
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Brain-Derived Neurotrophic Factor
- Interleukins
- Thiobarbituric Acid Reactive Substances
- Tumor Necrosis Factor-alpha
- BDNF protein, human
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Topics |
- Adult
- Biomarkers
(blood)
- Brain-Derived Neurotrophic Factor
(metabolism)
- Case-Control Studies
- Cross-Sectional Studies
- Female
- Fibromyalgia
(blood, metabolism)
- Humans
- Inflammation
(blood, metabolism)
- Interleukins
(blood)
- Oxidative Stress
(physiology)
- Prospective Studies
- Psychiatric Status Rating Scales
- Quality of Life
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Tumor Necrosis Factor-alpha
(blood)
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