Abstract | BACKGROUND: METHODS: RESULTS: Statistically significant associations were found between HERG1 expression and tobacco consumption, disease stage, tumor differentiation, tumor recurrence, and reduced survival. There was no association between HERG1 expression and the risk of progression from oral leukoplakia to OSCC. In addition, a high proportion of tumors (80%) showed increased HERG1 mRNA levels compared to normal mucosa from nononcologic patients. CONCLUSION: Aberrant HERG1 expression increases as oral tumorigenesis progresses from oral hyperplasia to OSCC. Increased HERG1 mRNA levels were also frequently detected in OSCC and other HNSCC subsites. HERG1 expression emerges as a clinically relevant feature during tumor progression and a potential poor prognostic biomarker for OSCC. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.
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Authors | Álvaro Fernández-Valle, Juan Pablo Rodrigo, Tania Rodríguez-Santamarta, M Ángeles Villaronga, Saúl Álvarez-Teijeiro, Juana M García-Pedrero, Laura Suárez-Fernández, Paloma Lequerica-Fernández, Juan Carlos de Vicente |
Journal | Head & neck
(Head Neck)
Vol. 38
Issue 11
Pg. 1672-1678
(11 2016)
ISSN: 1097-0347 [Electronic] United States |
PMID | 27131339
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2016 Wiley Periodicals, Inc. |
Chemical References |
- Biomarkers, Tumor
- Ether-A-Go-Go Potassium Channels
- KCNH1 protein, human
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Topics |
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Squamous Cell
(metabolism)
- Cell Proliferation
- Cell Transformation, Neoplastic
(metabolism)
- Disease Progression
- Ether-A-Go-Go Potassium Channels
(metabolism)
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Leukoplakia, Oral
(metabolism)
- Mouth Mucosa
(cytology, metabolism)
- Mouth Neoplasms
(metabolism)
- Prognosis
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