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RNA-Directed DNA Polymerase (Reverse Transcriptase)

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An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.

Also Known As:

Reverse Transcriptase; RNA Transcriptase; Revertase; DNA Polymerase, RNA Directed; DNA Polymerase, RNA-Dependent; RNA Dependent DNA Polymerase; RNA Directed DNA Polymerase; DNA Polymerase, RNA-Directed; RNA-Dependent DNA Polymerase; Deoxynucleotide-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)

Networked: 7057 relevant articles (124 outcomes, 676 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Hoon, Dave S B: 13 articles (11/2012 - 12/2002)
2.	Wainberg, Mark A: 12 articles (11/2015 - 02/2002)
3.	Nuovo, Gerard J: 12 articles (06/2014 - 09/2002)
4.	Mori, Masaki: 11 articles (05/2014 - 03/2007)
5.	Wang, Ying: 10 articles (01/2016 - 04/2004)
6.	Wang, Jian: 9 articles (02/2014 - 01/2004)
7.	Oshima, Takashi: 9 articles (10/2012 - 05/2008)
8.	Metzger, Ralf: 9 articles (09/2010 - 06/2004)
9.	Brabender, Jan: 9 articles (09/2010 - 06/2004)
10.	Vidaud, Michel: 9 articles (10/2008 - 03/2002)

Related Diseases

1.	Infection 01/01/2001 - "This agent was highly effective against HIV replication regardless of the addition period during early stages of infection (adsorption to integration) but did not inhibit reverse transcriptase activity directly. " 02/01/2007 - "To develop a novel treatment method for hepatitis B virus (HBV) infection, we aimed to make a human monoclonal antibody inhibiting reverse transcriptase (RT) activity of P protein which was important in HBV replication by using phage display technique. " 06/01/2010 - "With recent developments in rapid diagnostic methods like multiplex reverse transcriptase (RT)-PCR, R-mix virus culture, etc., early detection and effective treatment of respiratory viral infections is possible. " 10/01/2000 - "Triple combination therapy that includes a non-nucleoside reverse transcriptase inhibitor can therefore be regarded as an effective alternative first-line treatment of HIV-1 infection." 01/01/1990 - "Reverse transcriptase activity was present in control macaques only, implying that the subunit vaccine was protective against STLV-I infection."
2.	Acquired Immunodeficiency Syndrome (AIDS) 02/17/1995 - "The data suggest that an inhibitor combining the functionalities of a nonnucleoside inhibitor and a nucleotide analog could bind very tightly and specifically to reverse transcriptase and could be effective in the treatment of AIDS." 05/07/1992 - "These results have important implications for developing improved inhibitors of reverse transcriptase for the treatment of AIDS." 08/01/2006 - "We earlier reported that immunization of macaques with a reverse transcriptase-deleted SHIV(KU2) (DeltartSHIV(KU2)) plasmid that contained HIV-1(HXB2) env and SIV gag-nef induced protection against AIDS caused by challenge virus SHIV89.6P with a heterologous env. " 01/15/2016 - "AIDS Clinical Trials Group 5230 evaluated patients failing an initial nonnucleoside reverse-transcriptase inhibitor (NNRTI) regimen in Africa and Asia, comparing the genotypic drug resistance and phenotypic profile from the PhenoSense (Monogram). " 02/01/2013 - "APOBEC3G variants were detected using real-time polymerase chain reaction in HIV-1-infected children from Pediatric AIDS Clinical Trials Group (PACTG) protocols P152 and P300 that evaluated the effectiveness of 3 mono- or dual-nucleoside reverse transcriptase inhibitor treatments. "
3.	Neoplasms (Cancer) 05/01/2000 - "Molecular techniques, such as reverse-transcriptase polymerase chain reaction, may be useful tools to reach this target, but, today, immunocytochemistry is still considered the gold standard to assess new techniques to detect isolated tumor cells in hematopoietic tissue. " 05/01/2012 - "Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was conducted to analyze the expressions of miR-155 and its potential target genes in paired tumor tissues and adjacent tumor-free tissues and in disease-free liver tissue samples. " 01/01/1999 - "Several reports suggest that reverse transcriptase polymerase chain reaction (RT-PCR) holds great promise in the early staging of cancer patients in general. " 05/01/2014 - "Many of these reverse transcriptase/polymerase chain reaction-based techniques have been validated in archived tumor material from large phase III trials, and will soon be available to routine pathology laboratories as an aid in clinical decision-making for patients. " 01/01/2014 - "Whole transcriptome sequencing was used to study a small round cell tumor in which a t(4;19)(q35;q13) was part of the complex karyotype but where the initial reverse transcriptase PCR (RT-PCR) examination did not detect a CIC-DUX4 fusion transcript previously described as the crucial gene-level outcome of this specific translocation. "
4.	Human Influenza (Influenza) 04/01/2011 - "We assessed the test characteristics of Influenzatop®, a rapid immunochromatographic influenza A and B test, in detecting pandemic 2009 influenza A (H1N1) in children up to 18 years of age, using reverse transcriptase polymerase chain reaction (RT-PCR) as the gold standard. " 12/01/2012 - "Using the reverse transcriptase polymerase chain reaction as a gold standard, the overall sensitivity (0.57) was higher than that of the QuickVue Influenza A+B Test (0.43). " 09/01/2012 - "Patients were defined as being influenza-positive if the real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) test had positive results. " 05/01/2012 - "Although real-time reverse transcriptase-polymerase chain reactions (rRT-PCR) are gold standard for the diagnosis of influenza A (H1N1), the results can be delayed up to several days, which is problematic during a pandemic. " 05/01/2009 - "Culture has been the traditional gold standard for influenza diagnosis but requires from 1-10 days to generate a positive result, compared to nucleic acid detection methods such as real time reverse transcriptase polymerase chain reaction (RT-PCR). "
5.	Melanoma (Melanoma, Malignant) 02/01/2012 - "The objective is to evaluate the efficacy of SLNB in Japanese patients with primary cutaneous melanoma and to elucidate whether reverse transcriptase (RT)-PCR analysis of sentinel lymph nodes (SLNs) is valuable for predicting patient outcome. " 07/01/1999 - "The purpose of this study was to assess the prognostic significance of the detection of circulating melanoma cells by reverse transcriptase-PCR in long-term clinically disease-free melanoma patients. " 04/15/2000 - "We assessed the prognostic clinical utility of a multimarker melanoma reverse transcriptase-PCR (RT-PCR) assay using blood of 46 patients who were clinically disease-free. " 07/01/1999 - "Prognostic significance of the detection of circulating malignant cells by reverse transcriptase-polymerase chain reaction in long-term clinically disease-free melanoma patients." 07/01/2003 - "We hypothesized that a multiple-marker reverse transcriptase polymerase chain reaction (MM-RT-PCR) blood assay could predict, early in the course of therapy, those patients destined to experience treatment failure with a melanoma vaccine (MV) previously shown to improve survival in a phase II clinical trial. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	RNA (Ribonucleic Acid)
3.	tenofovir
4.	Protease Inhibitors (Protease Inhibitor)
5.	Antigens
6.	Isatin
7.	DNA (Deoxyribonucleic Acid)
8.	Keratin-19 (Keratin 19)
9.	Monophenol Monooxygenase (Tyrosinase)
10.	Immunoglobulin M (IgM)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Drug Therapy (Chemotherapy)
3.	Highly Active Antiretroviral Therapy (HAART)
4.	Art Therapy
5.	Aftercare (After-Treatment)