Potassium Channels (Potassium Channel)

03/06/2003 - "Na(+)-activated potassium channels (K(Na)) have been identified in cardiomyocytes and neurons where they may provide protection against ischemia. "
02/01/2013 - "The aim of this study was to find out whether opening of mitochondrial large-conductance Ca(2+)-activated potassium channels (BK(Ca)) protects cardiomyocytes against injury caused by simulated ischemia and reperfusion. "
07/01/2005 - "Many experimental studies have pointed out the controversy involving the arrhythmogenic effects of potassium channel openers (KCOs) in ischemia. "
10/01/2014 - "Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation."
08/01/2014 - "To explore the physiological and pathological significance of the 2-pore domain potassium channel TWIK-related K(+) (TREK)-1 in rat heart, its expression and role during heart development and cardiac ischemia were investigated. "

01/01/2014 - "Compounds that open the Ca2+- and voltage-activated potassium channel of big-conductance (BK) have a pre-conditioning-like effect on survival of cardiomyocytes after ischemia/reperfusion injury. "
11/02/2006 - "Preconditioning modulates pulmonary endothelial dysfunction following ischemia-reperfusion injury in the rat lung: role of potassium channels."
07/01/1993 - "Anti-ischaemic actions of potassium channel openers in experimental myocardial ischaemia/reperfusion injury in dogs."
09/30/2003 - "As a step in this direction, it was found that the heart was significantly protected against ischemia-reperfusion injury if it was first preconditioned by brief ischemia or by administering a potassium channel opener. "
08/01/1994 - "In both the stunned myocardium model as well as the infarcted myocardium model, the beneficial effects of the potassium channel openers could not be attributed to differences in the traditional determinants of the extent of ischaemia/reperfusion injury; area at risk size, oxygen consumption, or collateral blood flow. "

11/10/1998 - "Pretreatment with potassium channel openers (PCOs) has been shown to provide protective effects in the setting of myocardial ischemia. "
01/01/2009 - "There has been an increasing interest in compounds that modulate potassium ion channels (K(+)-channels) since they can be developed as important therapeutic agents against ischemic heart diseases. "
03/01/1995 - "Particular interest has focused on the question whether opening of potassium channels may be potentially arrhythmogenic in the setting of acute myocardial ischemia. "
01/01/1994 - "Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia."
03/01/1995 - "Potassium channel openers: clinical applications in ischemic heart disease--overview of clinical efficacy of nicorandil."

09/01/2014 - "Our previous study demonstrated that pregnancy increased large-conductance Ca(2+)-activated potassium channel β1 subunit (BKβ1) expression and large-conductance Ca(2+)-activated potassium channel activity in uterine arteries, which were abrogated by chronic hypoxia. "
01/01/2013 - "This study aimed to determine the role of SrcTK in hypoxia-induced inhibition of potassium channels in hPASMCs. "
09/01/2010 - "Our paper combines this correlation with the literature evidence on potassium channel inactivation and hypoxia response to identify specific motifs to serve as experimental targets for studies focused on this response. "
02/01/1995 - "More studies are needed to precisely define the individual potassium channels responsive to hypoxia and to confirm the gating mechanism. "
10/01/2015 - "[Effects of acute hypoxia on potassium channels in spiral ganglion cells of SD rats]."

01/01/1996 - "Furthermore, the increased understanding of myocardial repolarization that is gained from characterization of these genes may lead to improved treatment for other ventricular arrhythmias, including those related to potassium-channel blockade, central nervous system insult, and, possibly, myocardial infarction."
07/06/1996 - "The prophylactic use of a specific potassium-channel blocker does not reduce mortality, and may be associated with increased mortality in high-risk patients after myocardial infarction."
11/01/2008 - "Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction."
08/01/2006 - "A prospective, randomised, single centre study was designed to test the safety and efficacy of nicorandil infusion, a potassium channel opener, prior to reperfusion in ST-elevation acute myocardial infarction (STEMI). "
08/01/2014 - "The stability of dynamic factors has been reported to play a role in the antiarrhythmic actions of adenosine triphosphate (ATP)-sensitive potassium channel (KATP) opener in phase-2 myocardial infarction (MI) hearts. "