Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders.

Abstract

BACKGROUND:

Periapical periodontitis, also known as periapical lesion, is a common dental disease, along with periodontitis (gum disease). Periapical periodontitis is a chronic inflammatory disease, caused by endodontic infection, and its development is regulated by the host immune/inflammatory response. Metabolic disorders, which are largely dependent on life style such as eating habits, have been interpreted as a "metabolically-triggered" low-grade systemic inflammation and may interact with periapical periodontitis by triggering immune modulation. The host immune system is therefore considered the common fundamental mechanism of both disease conditions.

METHOD:

We have reviewed >200 articles to discuss the interrelationship between periapical lesions and metabolic disorders including type 2 diabetes mellitus, hypertension, and non-alcoholic fatty liver diseases (NAFLD), and their common pathological background in immunology/osteoimmunology and cytokine biology.

RESULTS:

An elevated inflammatory state caused by metabolic disorders can impact the clinical outcome of periapical lesions and interfere with wound healing after endodontic treatment. Although additional well-designed clinical studies are needed, periapical lesions appear to affect insulin sensitivity and exacerbate non-alcoholic steatohepatitis.

CONCLUSION:

Immune regulatory cytokines produced by various cell types, including immune cells and adipose tissue, play an important role in this interrelationship.

• Authors: Hajime Sasaki, Kimito Hirai, Christine M Martins, Hisako Furusho, Ricardo Battaglino, Koshi Hashimoto
• Journal: Current pharmaceutical design (Curr Pharm Des) Vol. 22 Issue 15 Pg. 2204-15 ( 2016) ISSN: 1873-4286 [Electronic] United Arab Emirates
• PMID: 26881444 (Publication Type: Journal Article, Review)

Chemical References

• Cytokines

Topics

• Cytokines (biosynthesis)
• Humans
• Inflammation (metabolism)
• Metabolic Diseases (metabolism)
• Periapical Periodontitis (metabolism)