The effects of Chamaecyparis obtusa essential oil on pain-related behavior and expression of pro-inflammatory cytokines in carrageenan-induced arthritis in rats.

Abstract

Chamaecyparis obtusa essential oil (COE) has been widely used to treat allergic diseases and was suggested to exert anti-inflammatory, antioxidant, and antimicrobial effects. This study evaluated the effects of COE on pain-related behavior and pro-inflammatory cytokines in rats with carrageenan (CGN)-induced arthritis. Reduced dynamic weight load on inflamed joint in voluntarily walking rats was used as the behavior test for arthritic pain; 10% COE-treated group was significantly attenuated pain (6-8 h post-CGN injection) compared to VEH (mineral oil)-treated group. In addition, the protein levels of interleukin (IL)-1β, tumor necrosis factor-α, IL-6 (6-8 h), and cyclooxygenase (COX)-2 (8 h) within the synovial membrane, as well as IL-1β, COX-2 (6-8 h), and IL-6 (5-7 h) within the meniscus, of 10% COE-treated group were significantly reduced. The current results implicate that COE has anti-inflammatory and anti-nociceptive effects on arthritis in rats.

• Authors: Hye Rim Suh, Hyun Joo Chung, Eui Ho Park, Sun Wook Moon, Su Jin Park, Chan Woo Park, Yang In Kim, Hee Chul Han
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 80 Issue 1 Pg. 203-9 ( 2016) ISSN: 1347-6947 [Electronic] England
• PMID: 26581235 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Interleukin-1beta
• Interleukin-6
• Oils, Volatile
• Plant Extracts
• Tumor Necrosis Factor-alpha
• Carrageenan
• Cyclooxygenase 2
• Ptgs2 protein, rat

Topics

• Analgesics (isolation & purification, pharmacology)
• Animals
• Anti-Inflammatory Agents (isolation & purification, pharmacology)
• Arthritis, Experimental (chemically induced, drug therapy, physiopathology)
• Carrageenan
• Chamaecyparis (chemistry)
• Cyclooxygenase 2 (genetics, metabolism)
• Gene Expression
• Interleukin-1beta (genetics, metabolism)
• Interleukin-6 (genetics, metabolism)
• Male
• Oils, Volatile (isolation & purification, pharmacology)
• Pain (chemically induced, drug therapy, physiopathology)
• Phytotherapy (methods)
• Plant Extracts (chemistry)
• Rats
• Rats, Sprague-Dawley
• Synovial Membrane (drug effects, physiopathology)
• Tumor Necrosis Factor-alpha (genetics, metabolism)