Abstract |
Allograft inflammatory factor-1 is the protein that expressed in the macrophages around the coronary arteries in rat ectopic cardiac allograft model. AIF-1 is produced mainly by macrophages and regulated by interferon-gamma (IFN-γ). There are various splicing valiants in AIF-1, and the functions are different. AIF-1 has Ca-binding EF-hand motif that induces cell proliferation and migration by structural features. Besides cell proliferation and migration, AIF-1 contributes to secretion of inflammatory cytokines and chemokines such as IL-6, IL-10, IL-12, and transforming growth factor-beta (TGF-β), insulin resistance by downregulation of GLUT4 or IRS-1, and fibrosis process by upregulation of collagen production. It has been elucidated that AIF-1 is responsible for the onset of various diseases such as rheumatoid arthritis and systemic sclerosis, atherosclerotic disease, diabetes mellitus. AIF-1 may have the therapeutic potential for chronic inflammatory diseases by elucidation of the mechanism.
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Authors | Aihiro Yamamoto, Yutaka Kawahito |
Journal | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology
(Nihon Rinsho Meneki Gakkai Kaishi)
Vol. 37
Issue 3
Pg. 139-45
( 2014)
ISSN: 1349-7413 [Electronic] Japan |
PMID | 24974925
(Publication Type: English Abstract, Journal Article, Review)
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Chemical References |
- DNA-Binding Proteins
- Nuclear Proteins
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Topics |
- Animals
- Arthritis, Rheumatoid
(immunology)
- Cell Proliferation
- DNA-Binding Proteins
(immunology)
- Humans
- Leucine Zippers
- Nuclear Proteins
(immunology)
- Scleroderma, Systemic
(immunology)
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