Abstract | PURPOSES: The purposes of this review were to discuss the role of exosomes in neurologic and psychiatric diseases and to propose future therapeutic approaches. METHODS: PubMed was searched (2000-2014) using the terms exosomes, microvesicles, neurological disorders, psychiatric disorders, multivesicular bodies, Alzheimer's disease, Parkinson's disease, prion disease, multiple sclerosis, schizophrenia, glioblastoma multiforme, and flavonoids. FINDINGS: IMPLICATIONS: Exosomes' simple structure and abilities to be incorporated into plasma membrane and to cross the blood-brain barrier allow for the opportunity to utilize them as delivery vehicles of drugs and genetic elements in the treatment of immune, psychiatric, and neurologic disorders. Flavonoids have emerged as unique, natural molecules with antioxidant and antiinflammatory properties. It would, therefore, be of interest to design flavonoid-containing exosomes.
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Authors | Irene Tsilioni, Smaro Panagiotidou, Theoharis C Theoharides |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 36
Issue 6
Pg. 882-8
(Jun 01 2014)
ISSN: 1879-114X [Electronic] United States |
PMID | 24913029
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2014 Elsevier HS Journals, Inc. All rights reserved. |
Topics |
- Alzheimer Disease
(physiopathology)
- Blood-Brain Barrier
(physiopathology)
- Central Nervous System Diseases
(physiopathology)
- Exosomes
(physiology)
- Humans
- Multiple Sclerosis
(physiopathology)
- Parkinson Disease
(physiopathology)
- Prion Diseases
(physiopathology)
- Schizophrenia
(physiopathology)
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