Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice.

Abstract

This study investigated the mechanism of processed tomato vinegar beverage (TVB)-mediated anti-obesity and anti-insulin resistance effects in high-fat diet (HF)-induced obese mice. Oral administration of TVB (14 mL kg(-1) body weight) to HF-fed mice for 6 weeks effectively reduced the body and visceral fat weight and significantly lowered plasma free fatty acid, triglyceride and hepatic triglyceride levels. TVB significantly increased fecal triglyceride excretion, both phosphorylated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) and peroxisome proliferator-activated receptor (PPAR)α protein levels in the liver, which were associated with increased fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice. TVB improved glucose tolerance, hyperinsulinemia and HOMA-IR levels in the HF + TVB group compared to the HF group. Additionally, TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, which enhanced glucose metabolism in obese mice. These results suggest that TVB prevents visceral obesity and insulin resistance via AMPK/PPARα-mediated fatty acid and glucose oxidation.

• Authors: Kwon-Il Seo, Jin Lee, Ra-Yeong Choi, Hae-In Lee, Ju-Hye Lee, Yong-Ki Jeong, Myung-Joo Kim, Mi-Kyung Lee
• Journal: Food & function (Food Funct) Vol. 5 Issue 7 Pg. 1579-86 (Jul 25 2014) ISSN: 2042-650X [Electronic] England
• PMID: 24867606 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Fatty Acids, Nonesterified
• Insulin
• PPAR alpha
• Triglycerides
• Cholesterol
• AMP-Activated Protein Kinases
• Acetyl-CoA Carboxylase
• Acetic Acid

Topics

• AMP-Activated Protein Kinases (metabolism)
• Acetic Acid (pharmacology)
• Acetyl-CoA Carboxylase (metabolism)
• Adipose Tissue (drug effects, metabolism)
• Animals
• Beverages (analysis)
• Blood Glucose (metabolism)
• Body Weight (drug effects)
• Cholesterol (blood)
• Diet, High-Fat (adverse effects)
• Fatty Acids, Nonesterified (blood)
• Food Handling
• Homeostasis (drug effects)
• Insulin (blood)
• Insulin Resistance
• Lipid Metabolism (drug effects)
• Liver (drug effects, metabolism)
• Solanum lycopersicum (chemistry)
• Male
• Mice, Inbred C57BL
• Mice, Obese
• Obesity (diet therapy, etiology)
• PPAR alpha (metabolism)
• Triglycerides (blood)