CROI 2013: Complications of HIV disease, viral hepatitis, and antiretroviral therapy.
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| Abstract |
Studies with direct-acting antivirals (DAAs) for hepatitis C virus (HCV) monoinfection and HIV coinfection were highlighted at the 2013 Conference on Retroviruses and Opportunistic Infections (CROI). In HCV monoinfected patients, several interferon alfa-sparing, all-oral regimens demonstrated cure rates of greater than 90% with 12 weeks of treatment, including for hard-to-treat patients. Cure rates of 75% were attained in HIV/HCV coinfected patients with the addition of the investigational HCV protease inhibitor (PI) simeprevir to peginterferon alfa and ribavirin. Drug-drug interaction data to inform safe coadminstration of antiretroviral therapy with DAA-based HCV treatment were presented. There was continued emphasis on pathogenesis, management, and prevention of the long-term complications of HIV disease and its therapies, including cardiovascular disease, renal disease, alterations in bone metabolism, and vitamin D deficiency, along with a growing focus on biomarkers to predict development of end-organ disease. Understanding the elevated risk for non-AIDS-defining malignancies in the HIV-infected population and optimal management was a focal point of this year's data. Finally, the conference provided important information on tuberculosis coinfection and cryptococcal meningitis.
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| Authors | Anne F Luetkemeyer, Diane V Havlir, Judith S Currier |
| Journal | Topics in antiviral medicine (Top Antivir Med) 2013 Apr-May Vol. 21 Issue 2 Pg. 62-74 ISSN: 2161-5853 [Electronic] United States |
| PMID | 23681961 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review) |
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