Abstract | OBJECTIVE:
Kaliotoxin (KTX) is a neurotoxin purified from Androctonus scorpion venom. Purification and pharmacological and immunological characterization of this neurotoxin has been extensively studied, but its biological effects have not. The ability of KTX to induce neuropathophysiological and immuno-inflammatory effects was investigated. METHODS: RESULTS: In this study, KTX injection induced severe alterations in the cerebral cortex, myocardium, and pulmonary parenchyma. Tissue damage was correlated with seric increase in creatine kinase and lactate dehydrogenase activities. KTX also induced an immuno-inflammatory response distinguished by cell infiltration characterized by a significant increase in EPO and MPO activities in the brain, heart, and lungs. This infiltration was also associated with an increase in albumin, α-, β-, and γ- globulin fractions, and NO release. CONCLUSION: KTX binding to its targets in CNS (Kv1.1 and Kv1.3 channels) may induce severe modifications in the structure and function of various organs associated with the activation of immuno-inflammatory reactions.
|
Authors | Amina Ladjel-Mendil, Marie-France Martin-Eauclaire, Fatima Laraba-Djebari |
Journal | Neuroimmunomodulation
(Neuroimmunomodulation)
Vol. 20
Issue 2
Pg. 99-106
( 2013)
ISSN: 1423-0216 [Electronic] Switzerland |
PMID | 23295619
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- Neurotoxins
- Scorpion Venoms
- kaliotoxin
|
Topics |
- Animals
- Brain
(pathology)
- Injections, Intraventricular
- Lung
(pathology)
- Mice
- Myocardium
(pathology)
- Neurotoxins
(administration & dosage, toxicity)
- Scorpion Venoms
(administration & dosage, toxicity)
|