Abstract | OBJECTIVE: Clinical manifestations and metabolic risk factors may differ in ethnic subgroups of patients with polycystic ovary syndrome (PCOS). DESIGN: Retrospective trans-sectional study. PATIENTS: One thousand and two premenopausal women with the diagnoses hirsutism or PCOS were divided according to ethnicity: Caucasian (CA, n = 784), Middle East (ME, n = 190), Asian (n = 14) and others (n = 14). MEASUREMENTS: RESULTS: (CA vs ME women) CA women were older [32(25-37) vs 25(18-32) years, median (quartiles)] and had increased BMI compared to ME women. After correcting for age and BMI, CA women were less hirsute, but had increased testosterone levels compared to ME women. The Rotterdam criteria were fulfilled in 56% of both populations, but PCO was diagnosed in 47% CA vs 29% ME women, P < 0·01. CA women had increased blood pressure and smoked at a higher frequency (40 vs 23%), whereas area under the curve for insulin during OGTT was decreased, all P < 0·001. Prolactin levels were significantly lower in CA women compared to ME women [7(5-10) vs 9(6-12) μg/l] and were inversely associated with smoking status. CONCLUSION: CA women had a more adverse cardiovascular profile than ME women, whereas insulin sensitivity was higher. The prevalence of the individual Rotterdam criteria differed significantly in the two study populations.
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Authors | Dorte Glintborg, Hanne Mumm, David Hougaard, Pernille Ravn, Marianne Andersen |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 73
Issue 6
Pg. 732-8
(Dec 2010)
ISSN: 1365-2265 [Electronic] England |
PMID | 20846294
(Publication Type: Journal Article)
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Copyright | © 2010 Blackwell Publishing Ltd. |
Chemical References |
- C-Peptide
- Insulin
- Sex Hormone-Binding Globulin
- Testosterone
- Prolactin
- Luteinizing Hormone
- Follicle Stimulating Hormone
- Hydrocortisone
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Topics |
- Adolescent
- Adult
- Asian People
- Body Mass Index
- C-Peptide
(blood)
- Female
- Follicle Stimulating Hormone
(blood)
- Glucose Tolerance Test
- Humans
- Hydrocortisone
(blood)
- Insulin
(blood)
- Luteinizing Hormone
(blood)
- Polycystic Ovary Syndrome
(blood, ethnology, metabolism)
- Premenopause
(blood)
- Prolactin
(blood)
- Retrospective Studies
- Risk Factors
- Sex Hormone-Binding Globulin
(metabolism)
- Testosterone
(blood)
- White People
- Young Adult
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