Abstract | INTRODUCTION:
Cancer and Leukemia Group B 9633 was a phase III trial that randomized patients with stage IB non-small cell lung cancer to observation or four cycles of carboplatin and paclitaxel. A statistically significant effect in favor of adjuvant chemotherapy was seen for disease-free survival (DFS) and overall survival (OS) in the subgroup of patients with tumors > or =4 cm. A laboratory companion study was conducted to see whether molecular and clinical factors could provide additional prognostic information. METHODS:
Formalin-fixed, paraffin-embedded blocks were obtained for 250 of the 344 patients enrolled. Immunohistochemical staining for bcl-2, p53, blood group antigen A, and mucin was correlated with DFS and OS. RESULTS: The prevalence of the markers was bcl-2, 17%; p53, 47%; blood group antigen A, 25%; and mucin, 45%. Univariate analysis for DFS showed a statistically significant effect for the presence of mucin (p = 0.0005) and p53 (p = 0.05) and for OS showed a significant effect for mucin (p = 0.0005). In the multivariate Cox model, there was a statistically significant association between shorter DFS and presence of mucin (p = 0.002; hazard ratio [HR] 2.05) and p53 (p = 0.003; HR 1.95) and between shorter OS and presence of mucin (p = 0.004; HR 2.03) and p53 (p = 0.0005; HR 2.30). Of the clinical factors, male gender and larger tumor volume were also significant adverse prognostic factors (p 0.05). CONCLUSIONS:
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Authors | Stephen L Graziano, Lin Gu, Xiaofei Wang, Arthur H Tatum, Robin T Vollmer, Gary M Strauss, Robert Kratzke, Arkadiusz Z Dudek, Everett E Vokes, Mark R Green, Cancer and Leukemia Group B, North Central Cancer Treatment Group, Radiation Therapy Oncology Group |
Journal | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
(J Thorac Oncol)
Vol. 5
Issue 6
Pg. 810-7
(Jun 2010)
ISSN: 1556-1380 [Electronic] United States |
PMID | 20521348
(Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- DNA-Binding Proteins
- Mucins
- Proto-Oncogene Proteins c-bcl-2
- Tumor Suppressor Protein p53
- ERCC1 protein, human
- Endonucleases
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(mortality, pathology)
- DNA-Binding Proteins
(analysis)
- Disease-Free Survival
- Endonucleases
(analysis)
- Female
- Humans
- Lung Neoplasms
(chemistry, mortality)
- Male
- Middle Aged
- Mucins
(analysis)
- Neoplasm Staging
- Prognosis
- Proto-Oncogene Proteins c-bcl-2
(analysis)
- Tumor Suppressor Protein p53
(analysis)
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