Paraffin

A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.

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Networked: 16116 relevant articles (149 outcomes, 1779 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cheng, Liang: 30 articles (07/2014 - 01/2002)
2.	Ross, Jeffrey S: 25 articles (08/2015 - 03/2002)
3.	Fountzilas, George: 24 articles (07/2015 - 11/2005)
4.	Höfler, Heinz: 23 articles (11/2014 - 09/2002)
5.	Danenberg, Kathleen D: 22 articles (05/2013 - 07/2002)
6.	Jeschke, Udo: 22 articles (01/2013 - 01/2003)
7.	Zhang, Wei: 21 articles (09/2015 - 02/2002)
8.	Dietel, Manfred: 21 articles (06/2015 - 06/2002)
9.	Danenberg, Peter V: 21 articles (01/2013 - 07/2002)
10.	Patsouris, Efstratios: 19 articles (10/2014 - 03/2002)

Related Diseases

1.	Neoplasms (Cancer) 03/01/1994 - "The availability of methods that are effective in paraffin sections may facilitate studies of the possible value of these markers as prognostic indicators for predicting the response of major tumors to different forms of therapy. " 01/01/1991 - "The main advantages of the procedure described are its greatly improved sensitivity, the increased speed with which tumor samples can be analyzed, and the possibility of using paraffin-embedded sections to analyze various rare tumors in retrospect." 08/01/1998 - "Immunohistochemical studies on the paraffin-embedded tissue and flow cytometry of fresh tissue helped characterize the neoplasm. " 01/01/2014 - "Assessment of the tumor border can be performed on standard paraffin sections and shows promise for integration into the diagnostic routine of gastrointestinal pathology. " 01/01/2012 - "The clinical gold standard for assessing microvessel density is CD105 immunohistochemistry on paraffin-embedded tumor specimens. "
2.	Carcinoma (Carcinomatosis) 09/01/1992 - "Improved immunohistochemical detection of p53 protein in paraffin--embedded tissues reveals elevated levels in most head and neck and lung carcinomas: correlation with clinicopathological parameters." 07/01/2000 - "Using a novel improved primer extension and preamplification polymerase chain reaction, we analyzed microdissected paraffin-embedded specimens of pancreatic carcinoma (n = 29) and their corresponding pancreatic intraductal lesions (PIL, n = 331) for loss of heterozygosity (LOH) of p16(INK4), DPC4, and p53 by microsatellite analysis and for p53 protein by immunohistochemistry. " 07/01/1991 - "An improved protocol for in situ hybridization (ISH) to routinely processed, paraffin-imbedded tissue sections from transitional bladder carcinoma (TCC) is presented. " 01/01/1991 - "Improved prognostic impact of S-phase values from paraffin-embedded breast and prostate carcinomas after correcting for nuclear slicing." 04/01/2015 - "Archival paraffin embedded 40 esophageal carcinoma specimens were retrieved for the study. "
3.	Infection 10/01/2014 - "The aim of this study was to compare the two different real-time polymerase chain reaction (Rt-PCR) system in the postmortem diagnosis of Mycobacterium tuberculosis infections in paraffin-embedded tissues. " 01/01/2014 - "The aim of this study was to evaluate the association between HPV infection and paraffin-embedded colorectal tissue samples in Mashhad in the northeast of Iran. " 02/01/2009 - "In this study the following methods for the diagnosis of Lawsonia intracellularis infection in pigs were compared in relation to a reference method (examination of ileal mucosal scrapings by the polymerase chain reaction [PCR]): Warthin-Starry (WS) staining of tissue sections, immunohistochemistry (IHC), in-situ hybridization (ISH), and PCR examination of faeces and of paraffin wax-embedded samples of ileum. " 03/01/2007 - "The results of the present study demonstrate that opportunistic amoebic infections can be diagnosed by PCR from paraffin-embedded biopsy material." 01/01/2007 - "Immunohistochemical detection of 3 viral infections in paraffin-embedded tissue from mink (Mustela vison): a tissue-microarray-based study."
4.	Lymphoma (Lymphomas) 04/01/2000 - "PCR-SSCP analysis in paraffin-embedded tissue section was very useful in the diagnosis of lymphoma cell monoclonality." 06/01/2002 - "The efficacy of this method to study paraffin-embedded tissue was investigated in six normal lymph nodes or tonsils and 32 malignant lymphomas including five mantle cell, five follicular, five Burkitt, five extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue, five anaplastic large-cell, and seven diffuse large B-cell. " 07/01/1987 - "Immunologic studies, which may be performed on paraffin-embedded tissue, are helpful in differentiating this lesion from the sclerosing lymphomas that also occur in the retroperitoneal area." 05/01/2008 - "Paraffin-embedded specimens of lymphoma collected between 1996 and 2005, including 36 Hodgkin lymphomas (HL) and 51 non-Hodgkin lymphomas (NHL), were included in this study. " 12/01/2005 - "In this study, FOXP3 protein expression has been analysed using a new anti-FOXP3 monoclonal antibody in 172 paraffin-embedded lymphoma samples. "
5.	Neoplasm Metastasis (Metastasis) 12/01/2012 - "The search for metastases in the SLN by imprint and histopathological analysis in paraffin compared to the gold standard (axillary dissection) had a low sensitivity with high rate of false negatives in our sample." 02/01/2012 - "Expression of target miRs in micro-dissected paraffin embedded tissues was evaluated in 15 primary tumours with adjacent normal tissue from patients that were disease-free at 4 years (cohort A) and 19 paired primary tumours with corresponding liver metastases (cohort B) by quantitative real-time PCR. " 01/01/2012 - "Our study has analyzed 34 paraffin blocks incoming from 20 cases with documented presence of metastatic invasion and 14 cases without metastases. " 07/21/2009 - "Furthermore, immunohistochemical study was performed using paraffin section of 154 primary ccRCCs and 24 metastases. " 02/01/2015 - "Eligibility requirements were histological proof of NSCLC, as well as sufficient quantity of paraffin-embedded lung and brain metastases specimens for EGFR mutation detection. "

Related Drugs and Biologics

1.	Formaldehyde (Formol)
2.	DNA (Deoxyribonucleic Acid)
3.	Antibodies
4.	Antigens
5.	Indicators and Reagents (Reagents)
6.	Monoclonal Antibodies
7.	Messenger RNA (mRNA)
8.	Codon (Codons)
9.	docetaxel (Taxotere)
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Drug Therapy (Chemotherapy)
3.	Ligation
4.	Hydrocolloid Bandages (Duoderm)
5.	Mohs Surgery (Mohs' Micrographic Surgery)