Abstract | BACKGROUND:
Hemorrhagic shock is the leading cause of potentially preventable death after traumatic injury. Hemorrhage and subsequent resuscitation may result in a dysfunctional systemic inflammatory response and multisystem organ failure, leading to delayed mortality. Clinical evidence supports improved survival and reduced morbidity when fresh blood products are used as resuscitation strategies. We hypothesized that the transfusion of fresh whole blood (FWB) attenuates systemic inflammation and reduces organ injury when compared with conventional crystalloid resuscitation after hemorrhagic shock. METHODS: Male mice underwent femoral artery cannulation and hemorrhage to a systolic blood pressure of 25 mm Hg +/- 5 mm Hg. After 60 minutes, the mice were resuscitated with either FWB or lactated Ringer's solution (LR). Mice were decannulated and killed at intervals for tissue histology, serum cytokine analysis, and vascular permeability studies. Separate groups of mice were followed for survival studies. RESULTS: CONCLUSIONS:
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Authors | Amy T Makley, Michael D Goodman, Lou Ann W Friend, Joseph S Deters, Jay A Johannigman, Warren C Dorlac, Alex B Lentsch, Timothy A Pritts |
Journal | The Journal of trauma
(J Trauma)
Vol. 68
Issue 2
Pg. 305-11
(Feb 2010)
ISSN: 1529-8809 [Electronic] United States |
PMID | 20154542
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Crystalloid Solutions
- Cytokines
- Isotonic Solutions
- Ringer's Lactate
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Topics |
- Animals
- Blood
- Blood Transfusion
- Crystalloid Solutions
- Cytokines
(blood)
- Inflammation
(prevention & control)
- Isotonic Solutions
- Male
- Mice
- Mice, Inbred C57BL
- Resuscitation
(methods)
- Ringer's Lactate
- Shock, Hemorrhagic
(therapy)
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