Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: Mice received an intraperitoneal (i.p.) injection of vehicle ( Tween 10%) or allopurinol (10-400 mg kg(-1)). Anti-nociceptive effects were measured with intraplantar capsaicin, intraplantar glutamate, tail-flick or hot-plate tests. KEY RESULTS: CONCLUSIONS AND IMPLICATIONS:
Allopurinol-induced anti-nociception may be related to adenosine accumulation. Allopurinol is an old and extensively used compound and seems to be well tolerated with no obvious central nervous system toxic effects at high doses. This drug may be useful to treat pain syndromes in humans.
|
Authors | A P Schmidt, A E Böhmer, C Antunes, C Schallenberger, L O Porciúncula, E Elisabetsky, D R Lara, D O Souza |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 156
Issue 1
Pg. 163-72
(Jan 2009)
ISSN: 1476-5381 [Electronic] England |
PMID | 19133997
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine
- Adenosine A1 Receptor Agonists
- Adenosine A1 Receptor Antagonists
- Adenosine A2 Receptor Antagonists
- Analgesics
- Narcotic Antagonists
- Pyrimidines
- Triazoles
- Xanthines
- Uric Acid
- Naloxone
- Glutamic Acid
- Allopurinol
- 1,3-dipropyl-8-cyclopentylxanthine
- Xanthine Oxidase
- Adenosine
- Capsaicin
|
Topics |
- Adenosine
(cerebrospinal fluid)
- Adenosine A1 Receptor Agonists
- Adenosine A1 Receptor Antagonists
- Adenosine A2 Receptor Antagonists
- Allopurinol
(pharmacology, therapeutic use)
- Analgesics
(pharmacology, therapeutic use)
- Animals
- Capsaicin
- Dose-Response Relationship, Drug
- Glutamic Acid
- Hot Temperature
- Injections, Intraperitoneal
- Male
- Mice
- Naloxone
(pharmacology)
- Narcotic Antagonists
(pharmacology)
- Pain
(drug therapy, etiology)
- Pain Measurement
- Pyrimidines
(pharmacology)
- Triazoles
(pharmacology)
- Uric Acid
(cerebrospinal fluid)
- Xanthine Oxidase
(antagonists & inhibitors)
- Xanthines
(pharmacology)
|