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Naloxone (Narcan)

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.

Also Known As:

Narcan; Abello Brand of Naloxone Hydrochloride; Boots Brand of Naloxone Hydrochloride; Bristol-Myers Squibb Brand of Naloxone Hydrochloride; Curamed Brand of Naloxone Hydrochloride; Endo Brand of Naloxone Hydrochloride; Lamepro Brand of Naloxone Hydrochloride; MRZ 2593-Br; MRZ-2593; Nalone; Naloxon Curamed; Naloxon-ratiopharm; Naloxone Abello; Naloxone Hydrobromide; Naloxone Hydrochloride; Naloxone Hydrochloride Dihydride; Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer; Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer; Narcanti; SERB Brand of Naloxone Hydrochloride; United Drug Brand of Naloxone Hydrochloride; ratiopharm Brand of Naloxone Hydrochloride; Abello, Naloxone; Bristol Myers Squibb Brand of Naloxone Hydrochloride; Curamed, Naloxon; Dihydride, Naloxone Hydrochloride; Hydrobromide, Naloxone; Hydrochloride Dihydride, Naloxone; Hydrochloride, Naloxone; MRZ 2593; MRZ 2593 Br; MRZ 2593Br; MRZ2593; Naloxon ratiopharm; Naloxonratiopharm; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-

Networked: 4163 relevant articles (258 outcomes, 439 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Bruehl, Stephen: 11 articles (05/2014 - 09/2002)
2.	Hopp, Michael: 10 articles (12/2015 - 11/2008)
3.	Dahan, Albert: 10 articles (01/2012 - 02/2003)
4.	Ling, Walter: 9 articles (12/2015 - 09/2003)
5.	Tamaddonfard, Esmaeal: 9 articles (09/2015 - 08/2007)
6.	Fiellin, David A: 9 articles (02/2015 - 03/2011)
7.	Zarrindast, Mohammad-Reza: 9 articles (04/2014 - 05/2002)
8.	Reimer, Karen: 8 articles (12/2015 - 11/2008)
9.	Burns, John W: 8 articles (05/2014 - 09/2002)
10.	Capasso, Anna: 8 articles (11/2010 - 02/2002)

Related Diseases

1.	Pain (Aches) 03/01/1987 - "Twenty-two patients who experienced excellent pain relief from chronic PAG-PVG stimulation received intravenous naloxone in a double-blind, placebo-controlled protocol. " 08/01/1986 - "Patients receiving naloxone had significantly greater intraoperative i beta-END and pain as compared with those receiving placebo. " 01/01/1983 - "EP amplitude enhancement with naloxone was significantly greater following 20 min of shocks than preceding them, while pain judgments were not significantly affected. " 01/01/2004 - "The reduction of the naloxone infusion rate effectively relieved the increased pain, and no supplemental analgesic was used in any patients during the naloxone infusion. " 01/01/2000 - "His pain was relieved with naloxone. "
2.	Respiratory Insufficiency (Respiratory Failure) 01/01/2014 - "Protective effects have been observed with training individuals at high risk of overdose and prescribing them naloxone, an opioid antagonist that reverses the effects of the opioid-induced respiratory depression that causes death. " 12/01/1980 - "Respiratory depression was treated successfully with naloxone." 05/12/2014 - "Intranasal naloxone is as effective as IV naloxone in reversing both respiratory depression and depressive effects on the central nervous system caused by opioid overdose." 01/03/2005 - "IN naloxone is effective in treating opiate-induced respiratory depression, but is not as effective as IM naloxone. " 09/05/2014 - "While, a single injection of naloxone (150.0 μg/kg, i.m.) only achieved partial remission of respiratory depression. "
3.	Shock 06/01/2002 - "Pretreatment with naloxone before HS attenuated the protective effects in a dose-dependent fashion, with significant attenuation of protection occurring at 15 mg/kg naloxone versus heat shock (42 +/- 6 vs. 16 +/- 3%, P < 0.001). " 11/01/1988 - "Naloxone treatment improved blood pressure significantly during endotoxin shock, as would be expected with the observed increase in total peripheral vascular resistance and no significant change in cardiac output. " 08/01/1980 - "In endotoxin shock in rats, naloxone's effects were stereospecific and were observed with intravenous (iv) doses as low as 0.1 mg/kg. In endotoxin shock in dogs, naloxone treatment significantly improved both cardiovascular parameters and survival. " 01/01/2003 - "Many case reports have suggested that naloxone (an opiate antagonist) might be an effective treatment for shock in humans, but others have not supported such a point of view. " 10/01/1989 - "Naloxone and shed blood were equally effective in improving hepatic and renal blood flow; gastric, intestinal, pancreatic, and splenic blood flow remained unchanged from shock values in both groups. "
4.	Pruritus (Itching) 08/01/2011 - "Some of those studies indicated a significant reduction in the frequency or severity of pruritus with use of naloxone (a low-dose, continuous i.v. infusion of naloxone appeared to be the most effective treatment). " 07/01/1985 - "Intravenous naloxone significantly decreased the incidence of pruritus during labor and delivery. " 10/01/1997 - "Naloxone had been shown to be effective in relieving pruritus of dialyzed patients. " 09/01/2009 - "Naloxone is safe and efficacious in symptomatic improvement in cholestatic pruritus." 07/01/2011 - "Analgesic efficacy of intravenous naloxone for the treatment of postoperative pruritus: a meta-analysis."
5.	Constipation 08/01/2015 - "An international double-blind randomized placebo controlled study evaluated the safety and efficacy of four doses of a new sustained release naloxone capsule to treat Opioid Induced Constipation (OIC). " 10/01/2014 - "Enteral naloxone may be effective in treating opioid-induced constipation; however, further studies are warranted." 10/01/2014 - "To determine the safety and efficacy of enteral naloxone for the treatment of opioid-induced constipation in the medical intensive care unit (MICU). " 03/01/1997 - "In conclusion, it was found that the treatment of opioid-induced constipation by administration of oral naloxone produced positive results. " 07/01/1992 - "Oral naloxone ameliorates opioid-induced constipation in opioid-dependent persons. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Oxycodone (Oxycontin)
3.	Opioid Receptors (Opioid Receptor)
4.	Buprenorphine (Subutex)
5.	Naltrexone (ReVia)
6.	Nalbuphine (Nubain)
7.	Opioid Analgesics (Opioids)
8.	Narcotic Antagonists (Opioid Antagonists)
9.	Dexamethasone (Maxidex)
10.	Benzodiazepines

Related Therapies and Procedures

1.	Analgesia
2.	Injections
3.	Resuscitation
4.	Intravenous Injections
5.	Ligation