[Modulation of the cholinergic system during inflammation].

Abstract

This review describes the effects of realization of the central and peripheral "cholinergic antiinflammatory pathway" in a model of endotoxic and anaphylactic shock. Under endotoxic shock conditions, a pharmacological correction by means of the central m-cholinomimetic action (electrical stimulation of the distal ends of nervus vagus after bilateral cervical vagotomy, surgical implantation of the stimulant devise, activation of efferent vagal neurons by means of muscarinic agonist) is directed toward the elimination of LPS-induced hypotension. During the anaphylaxis, peripheral effects of the cholinergic system induced by blocking m-AChR on the target cells (neuronal and non-neuronal lung cells) and acetylcholinesterase inhibition are related to suppression of the bronchoconstrictor response. The role of immune system in the pathogenesis of endotoxic shock is associated with the production of proinflammatory cytokines by macrophages, increase in IgM concentration, and complement activation, while the role in the pathogenesis of anaphylactic shock is associated with IgE, IgG1 augmentation. Effects of B cell stimulation may be important in hypoxia and in the prophylaxis of stress ulcers and other diseases. Plasma proteins can influence the effects of the muscarinic antagonist methacine: IgG enhance its action while albumin and CRP abolish it.

• Authors: G I Nezhinskaia, A L Vladykin, N S Sapronov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2008 Mar-Apr Vol. 71 Issue 2 Pg. 65-9 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 18488913 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Blood Proteins
• Cholinergic Agonists
• Cholinergic Antagonists
• Immunoglobulin G
• Receptors, Muscarinic
• Receptors, Nicotinic

Topics

• Anaphylaxis (immunology, physiopathology)
• Animals
• Blood Proteins (immunology)
• Cholinergic Agonists (pharmacology)
• Cholinergic Antagonists (pharmacology)
• Humans
• Immunoglobulin G (immunology)
• Inflammation (immunology, physiopathology)
• Receptors, Muscarinic (immunology, physiology)
• Receptors, Nicotinic (immunology, physiology)
• Respiratory Mucosa (immunology)
• Shock, Septic (immunology, physiopathology)
• Vagus Nerve (physiopathology)