Cholinergic Agents (Cholinergics)

Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.

Also Known As:

Networked: 368 relevant articles (25 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Grando, Sergei A: 3 articles (10/2014 - 04/2006)
2.	Keyser, Kent T: 3 articles (05/2010 - 09/2005)
3.	Strang, Christianne E: 3 articles (05/2010 - 09/2005)
4.	Osman, Nadir I: 2 articles (04/2014 - 12/2013)
5.	Chapple, Christopher R: 2 articles (04/2014 - 12/2013)
6.	Sambeth, Anke: 2 articles (08/2013 - 02/2013)
7.	Klinkenberg, Inge: 2 articles (08/2013 - 02/2013)
8.	Blokland, Arjan: 2 articles (08/2013 - 02/2013)
9.	Sakakibara, Ryuji: 2 articles (01/2013 - 06/2006)
10.	Yamamoto, Tatsuya: 2 articles (01/2013 - 06/2006)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 07/01/2003 - "Alzheimer disease (AD) treatment guidelines state that cholinergic agents are not cost-effective in patients with more severe disease. " 05/01/2010 - "The synthesis and the AChE/BuChE inhibition studies are reported, confirming that compound 2 is a potent and selective AChE inhibitor, and consequently, a new lead compound for further development into new dual CAS/PAS cholinergic agents for the treatment of Alzheimer's disease." 02/01/2005 - "A few studies have suggested that cholinomimetics or AChE inhibitors can improve memory functions not only in Alzheimer's disease but also in other pathologies. " 01/01/2002 - "However, with the advent of new cholinergic agents now used for treating Alzheimer's disease, scope exists for more informative trials. " 01/01/1989 - "After a decade of intense study of cholinergic therapies for Alzheimer's disease, three conditions in this field are apparent: 1) The potential that cholinergic agents will ameliorate the memory dysfunction of Alzheimer patients (as 1-dopa benefits Parkinson patients) is still a stimulus for research. "
2.	Movement Disorders (Movement Disorder) 01/01/2002 - "Cholinergic drugs did not result in any substantial improvement in tardive dyskinesia symptoms when compared with placebo (8 RCTs, 170 people, RR no important improvement 0.84 CI 0.68 to 1.04). " 11/01/2004 - "Systematic review of cholinergic drugs for neuroleptic-induced tardive dyskinesia: a meta-analysis of randomized controlled trials." 01/01/2002 - "If these new cholinergic agents are to be investigated for treating people with tardive dyskinesia, their effects should be demonstrated in well-designed, conducted and reported randomised trials." 11/01/2004 - "Further investigation of the clinical effects of novel cholinergic agents in tardive dyskinesia is warranted." 11/01/2004 - "Cholinergic drugs showed a minor trend for improvement of tardive dyskinesia symptoms, but results were not statistically significant (RR 0.84, 95% confidence interval (CI) 0.68 to 1.04, p=0.11). "
3.	Seizures (Seizure) 06/01/2015 - "In animal models, restoration of theta by sensory stimulation, septal electrical stimulation or cholinergic drugs infused into septum ameliorates seizures. " 01/01/2000 - "In 1983, we reported that intracerebral or systemic administration of cholinergic agents produced seizures and seizure-related brain damage in rodents. " 09/01/1999 - "Myoclonic and tonic seizures elicited by microinjection of cholinergic drugs into the inferior colliculus." 06/22/1990 - "None of the rats pretreated with saline had seizures when given doses of cholinomimetics alone. " 12/15/1983 - "Cholinomimetics produce seizures and brain damage in rats."
4.	Dementia (Dementias) 01/01/2015 - "BF cholinergic cell loss in dementia and the sedative effect of anti-cholinergic drugs have long implicated these neurons as important for cognition and wakefulness. " 01/01/2006 - "Widely used current treatments for dementia include extracts of Ginkgo biloba and several alkaloidal, and therefore toxic, plant-derived cholinergic agents. " 01/01/2006 - "Effects of cholinergic drugs and cognitive training on dementia: 2-year follow-up." 01/01/2004 - "Effects of cholinergic drugs and cognitive training on dementia." 04/01/1999 - "The effects of cholinergic drugs proposed for treatment of cognitive impairment in normal aging and dementia on divided attention have been little studied in non-human primates. "
5.	Schizophrenia (Dementia Praecox) 05/21/2014 - "It has been shown that cholinergic system plays an important role in schizophrenia-associated cognitive deficits, therefore cholinergic drugs are novel targets for the treatment of cognitive deficits seen in schizophrenia. " 08/01/2013 - "Changes in auditory processing and sensory gating induced by cholinergic drugs may serve as a translational model for aging instead of schizophrenia. " 02/01/2013 - "It remains to be seen whether the effects of cholinergic drugs on AEPs are specifically related to the abnormalities found in schizophrenia. " 01/01/1979 - "Adrenergic and cholinergic drugs as episode and vulnerability markers of affective disorders and schizophrenia." 01/01/2015 - "Assessing the synergy between cholinomimetics and memantine as augmentation therapy in cognitive impairment in schizophrenia. "

Related Drugs and Biologics

1.	Lecithins
2.	Deanol (Dimethylethanolamine)
3.	Cholinesterase Inhibitors (Anticholinesterases)
4.	Choline (Choline Chloride)
5.	Arecoline (Arecolin)
6.	Physostigmine
7.	Meclofenoxate (Centrophenoxine)
8.	2- ethyl- 8- methyl- 2,8- diazaspiro(4,5)decane- 1,3- dione (RS 86)
9.	Acetylcholine (Acetylcholine Chloride)
10.	Cholinergic Antagonists (Anticholinergics)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Injections
3.	Aftercare (After-Treatment)
4.	Drug Therapy (Chemotherapy)
5.	Denervation