Acetylcholinesterase

An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.

Also Known As:

Networked: 2783 relevant articles (125 outcomes, 282 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kuca, Kamil: 23 articles (01/2016 - 11/2005)
2.	Soreq, Hermona: 19 articles (11/2015 - 12/2002)
3.	Worek, Franz: 16 articles (02/2015 - 12/2005)
4.	Sáez-Valero, Javier: 14 articles (07/2014 - 05/2002)
5.	Thiermann, Horst: 12 articles (02/2015 - 03/2003)
6.	Vidal, Cecilio J: 11 articles (11/2015 - 03/2002)
7.	Soreq, H: 11 articles (01/2015 - 02/2000)
8.	Pohanka, Miroslav: 10 articles (01/2015 - 06/2009)
9.	Greig, Nigel H: 10 articles (01/2014 - 05/2004)
10.	Inestrosa, Nibaldo C: 10 articles (01/2013 - 04/2002)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 12/01/2015 - "In this context, acetylcholinesterase (AChE) inhibitors comprise one type of the compounds most actively studied in the search for an effective treatment of symptoms of Alzheimer's disease. " 01/01/2012 - "Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic improvement in Alzheimer's disease (AD) because cholinergic deficit is a consistent and early finding in AD. " 01/01/2006 - "As a consequence of their capability to simultaneously interact with two binding sites of the same biological target (the enzyme acetylcholinesterase in most cases), to expand their interaction in the main binding site of the target molecule, or to interact with two different biological targets of interest in the pathogenesis of the disease, these dimeric or hybrid compounds exhibit an improved pharmacological profile including high affinity interactions, additional non conventional actions or complementary actions, what makes them potential drug candidates for the treatment of Alzheimer's disease. " 10/08/1998 - "Acetylcholinesterase (AChE) inhibitors are one of the most actively investigated classes of compounds in the search for an effective treatment of Alzheimer's disease. " 10/01/2010 - "Acetylcholinesterase (AChE) inhibitors played an important role in developing a cure for Alzheimer' s disease. "
2.	Poisoning 12/15/2005 - "We investigated whether transcriptional inducers could enhance the expression of acetylcholinesterase (AChE) in cell lines to achieve protection against organophosphate (OP) poisoning. " 03/01/2011 - "The aim of this study was to determine whether the Glasgow coma scale (GCS), and serum acetylcholinesterase and leukocyte levels have prognostic value in acute OP poisoning. " 01/05/2007 - "Thus, acetylcholinesterase activity is the main parameter investigated in studies searching for target sites following nerve agent poisoning." 01/01/1995 - "The conclusions derived from salient experimental and clinical studies are that intermediate syndrome relates to the severity of poisoning not the specific organophosphate and to prolonged inhibition of acetylcholinesterase activity of the erythrocytes, brain and muscle endplate with pre and post synaptic impairment of neuromuscular transmission. " 01/01/2015 - "Acute poisonings with this class of insecticide are reported among agricultural workers and children around the globe, due to the inhibition of acetylcholinesterase (AChE). "
3.	Dementia (Dementias) 01/01/2013 - "A PET study showed decreased acetylcholinesterase (AChE) activity in the fronto-parietal cortex, as well as a correlation between cortical AChE activity and mini-mental state examination score in CBS patients, suggesting that cholinergic stimulant therapy may be effective for dementia in CBS. " 01/01/2004 - "In conclusion, 5-I-A-85380 is clearly a useful ligand for both in vitro and in vivo single photon emission tomography human studies investigating disease symptoms and progression, response to acetylcholinesterase-inhibiting drugs and in differentiating primary degenerative dementia from VaD." 11/01/2000 - "Acetylcholinesterase inhibition in dementia with Lewy bodies: results of a prospective pilot trial." 12/01/1999 - "Further pharmacoeconomic studies are needed to determine the exact impact of acetylcholinesterase-inhibitor therapy on the overall costs of care for individuals with dementia." 11/01/2015 - "Dementia was assessed in terms of increase in brain acetylcholinesterase (AChE) activity and attenuation of learning ability (escape latency time) and memory retention (time spent in target quadrant) using Morris water maze. "
4.	Hirschsprung Disease (Hirschsprung's Disease) 01/01/2008 - "Over the last four decades, acetylcholinesterase enzyme histochemistry has proven to be the gold standard for the diagnosis of Hirschsprung disease and is one of the most commonly applied enzyme histochemical methods today. " 09/01/2015 - "Rectal suction biopsy (RSB) combined with acetylcholinesterase (AChE) staining is currently the gold standard for the diagnosis of Hirschsprung's disease (HD). " 05/01/2015 - "Acetylcholinesterase (AChE) staining has become the gold standard for definitively diagnosing Hirschsprung disease (HD), although some pitfalls have been reported. " 06/15/1977 - "An improved method for the determination of acetylcholinesterase activity in rectal biopsy tissue from patients with Hirschsprung's disease." 09/01/2008 - "The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung's disease (HD). "
5.	Dyspepsia (Indigestion) 06/01/2012 - "BACKGROUND Acotiamide hydrochloride (acotiamide), a novel selective acetylcholinesterase (AChE) inhibitor, has proven significantly effective in treating functional dyspepsia (FD) in clinical trials, particularly in alleviating meal-related symptoms. " 06/01/2012 - "To determine the efficacy of acotiamide, an acetylcholinesterase inhibitor, in patients with functional dyspepsia (FD) in a 4-week trial. " 03/01/2007 - "Itopride, a dopamine D2 antagonist and acetylcholinesterase inhibitor, significantly improved symptoms in patients with functional dyspepsia in one phase II randomized trial. " 02/23/2006 - "We assessed the efficacy of itopride, a dopamine D2 antagonist with anti-acetylcholinesterase [corrected] effects, in patients with functional dyspepsia. "

Related Drugs and Biologics

1.	donepezil (Aricept)
2.	Tacrine (Cognex)
3.	Soman
4.	Obidoxime Chloride (Obidoxime)
5.	Butyrylcholinesterase
6.	Galantamine (Galanthamine)
7.	Acetylcholine (Acetylcholine Chloride)
8.	HI 6 (H16)
9.	tabun
10.	huperzine A

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Palliative Care (Palliative Medicine)
4.	Intravenous Injections
5.	Colostomy