Abstract | BACKGROUND: METHODS: Control and streptozotocin-diabetic mice were randomized to receive rosiglitazone (20 mg/kg/day), gemfibrozil (100 mg/kg/day), or compound 3q (3 mg/kg/day) by gavage, or no treatment for a period of 20 weeks. Renal fibrosis was assessed by standard histology and collagen IV immunohistochemistry. Kidney function was assessed by urinary albumin excretion and creatinine clearance. RESULTS: Diabetes in this model was associated with an increase in glomerulosclerosis, tubulointerstitial fibrosis and increased collagen IV deposition in the glomeruli and tubules. All three agents significantly attenuated glomerulosclerosis, tubulointerstitial expansion and collagen IV deposition. The increase in albuminuria and the decline in kidney function associated with diabetes in this model were also attenuated by each of these agents, with no superiority observed among various treatment groups. These renoprotective effects were observed in the absence of changes in glucose, insulin or lipid levels or a reduction in blood pressure. CONCLUSIONS:
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Authors | Anna C Calkin, Sara Giunti, Karin A Jandeleit-Dahm, Terri J Allen, Mark E Cooper, Merlin C Thomas |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 21
Issue 9
Pg. 2399-405
(Sep 2006)
ISSN: 0931-0509 [Print] England |
PMID | 16720596
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins E
- Collagen Type IV
- Hypoglycemic Agents
- Hypolipidemic Agents
- PPAR alpha
- PPAR gamma
- Thiazolidinediones
- Rosiglitazone
- Creatinine
- Gemfibrozil
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Topics |
- Animals
- Apolipoproteins E
(metabolism)
- Collagen Type IV
(metabolism)
- Creatinine
(urine)
- Diabetic Nephropathies
(drug therapy, metabolism, pathology)
- Disease Models, Animal
- Disease Progression
- Gemfibrozil
(therapeutic use)
- Hypoglycemic Agents
(therapeutic use)
- Hypolipidemic Agents
(therapeutic use)
- Male
- Mice
- Mice, Knockout
- PPAR alpha
(agonists)
- PPAR gamma
(agonists)
- Rosiglitazone
- Thiazolidinediones
(therapeutic use)
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