Abstract | OBJECTIVE: METHOD:
BDNF Val66Met genotyping was performed in 27 matched pairs of schizophrenia and comparison subjects. The impact of this polymorphism on prefrontal cortex GAD(67) mRNA expression in schizophrenia subjects was assessed by comparing within-pair differences in GAD(67) mRNA expression between schizophrenia subjects with versus without the Met66 allele after the level of BDNF mRNA expression was controlled. RESULTS: In contrast to expectations, the within-pair reduction in GAD(67) mRNA expression was not greater in schizophrenia subjects who were hetero- or homozygous for the Met66 allele. These subjects did tend to exhibit less marked within-pair reductions in both GAD(67) and BDNF mRNA expression compared with schizophrenia subjects homozygous for the Val allele. CONCLUSIONS: The presence of the BDNF Met66 allele does not contribute to the decreased level of GAD(67) mRNA expression in the prefrontal cortex of subjects with schizophrenia.
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Authors | Takanori Hashimoto, David A Lewis |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 163
Issue 3
Pg. 534-7
(Mar 2006)
ISSN: 0002-953X [Print] United States |
PMID | 16513879
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Brain-Derived Neurotrophic Factor
- Isoenzymes
- RNA, Messenger
- gamma-Aminobutyric Acid
- Methionine
- Receptor, trkB
- Glutamate Decarboxylase
- glutamate decarboxylase 1
- Diazepam
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Topics |
- Brain-Derived Neurotrophic Factor
(genetics, metabolism)
- Cohort Studies
- Diazepam
(metabolism)
- Female
- Gene Expression
- Gene Frequency
- Genotype
- Glutamate Decarboxylase
(genetics, metabolism)
- Humans
- Isoenzymes
(genetics, metabolism)
- Male
- Methionine
- Polymorphism, Single Nucleotide
- Prefrontal Cortex
(metabolism)
- RNA, Messenger
(genetics, metabolism)
- Receptor, trkB
(genetics, metabolism)
- Schizophrenia
(genetics, metabolism)
- gamma-Aminobutyric Acid
(biosynthesis)
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