Abstract | BACKGROUND AND AIMS: Gastric acid secretion is downregulated by Helicobacter pylori infection and upregulated after its eradication, but the mechanisms are still unclear. We examined the effects of H pylori eradication on the number of parietal cells and on expression of molecules functioning in acid secretion in the human gastric mucosa. METHODS: RESULTS: CONCLUSIONS: In the absence of alteration of parietal cell number, gastric H+/K+-ATPase mRNA expression was markedly restored after successful H pylori eradication, suggesting a central role for the restoration of H+/K+- ATPase expression in gastric acid secretion recovery after H pylori eradication.
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Authors | H Osawa, H Kita, H Ohnishi, H Hoshino, H Mutoh, Y Ishino, E Watanabe, K Satoh, K Sugano |
Journal | Gut
(Gut)
Vol. 55
Issue 2
Pg. 152-7
(Feb 2006)
ISSN: 0017-5749 [Print] England |
PMID | 15872000
(Publication Type: Journal Article)
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Chemical References |
- RNA, Messenger
- H(+)-K(+)-Exchanging ATPase
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Topics |
- Chronic Disease
- Follow-Up Studies
- Gastric Mucosa
(pathology)
- Gastritis
(enzymology, microbiology, pathology)
- Gene Expression Regulation, Enzymologic
- H(+)-K(+)-Exchanging ATPase
(biosynthesis, genetics)
- Helicobacter Infections
(drug therapy, enzymology, pathology)
- Helicobacter pylori
- Humans
- Middle Aged
- Parietal Cells, Gastric
(pathology)
- RNA, Messenger
(genetics)
- Reverse Transcriptase Polymerase Chain Reaction
(methods)
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