Interleukin-1beta (Interleukin 1 beta)

An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.

Also Known As:

Networked: 6153 relevant articles (112 outcomes, 621 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Konturek, S J: 15 articles (08/2010 - 05/2000)
2.	Tsai, Fuu-Jen: 14 articles (12/2010 - 03/2002)
3.	Mazzon, Emanuela: 14 articles (04/2009 - 01/2002)
4.	Cuzzocrea, Salvatore: 14 articles (04/2009 - 01/2002)
5.	Tomaszewska, R: 12 articles (08/2010 - 06/2000)
6.	Warzecha, Z: 12 articles (08/2010 - 06/2000)
7.	Ceranowicz, P: 12 articles (08/2010 - 06/2000)
8.	Konturek, P C: 10 articles (08/2010 - 05/2000)
9.	Lin, Mao-Tsun: 10 articles (06/2010 - 03/2002)
10.	Tsai, Chang-Hai: 9 articles (12/2010 - 06/2002)

Related Diseases

1.	Necrosis 09/01/2004 - "Moreover, elevated interleukin-1beta and tumour necrosis factor-alpha titres were noticed in the pre-infected but not in cured animals. " 06/01/1998 - "It is noteworthy that although interleukin-1beta and tumour necrosis factor-alpha provoked an anxiogenic response in the elevated plus maze test of anxiety, neither cytokine significantly altered amygdaloid noradrenergic or serotonergic activity, as many previous studies have implicated increased amygdaloid noradrenergic and/or serotonergic activity in the pathophysiology of anxiety." 07/01/1994 - "In this study, we compared the effects of interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) on in vitro rat gastric fundus motility. " 12/01/2015 - "Exogenous MGF-E peptide has no obvious cytotoxic effects on OA-FLS and promotes LOX expression in OA-FLS, induce apoptosis and ER stress and down-regulate protein levels of tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β). " 10/01/2015 - "Of the cytokine-related genes examined, interleukin-1beta (IL-1β) and tumour necrosis factor-alpha (TNF-α) were up-regulated in the head-kidney, intestine, and hepatopancreas of fish fed experimental diets, and expression was significantly higher in G2 and G3 than in the control group. "
2.	Inflammation 01/01/2015 - "In conclusion, patient PBMCs are hyperresponsive to LPS, and clinical efficacy of IL-1 beta inhibition in patients with SchS is associated with in-vivo and ex-vivo suppression of inflammation. " 12/01/2015 - "And these ameliorative effects of GE treatment were involved with regulating CUMS-induced pro-inflammatory cytokine interleukin-1 beta (IL-1β) related neuro-inflammation. " 11/01/2015 - "In the TPA-induced inflammation model, the resin formulation significantly reduced ear thickness and interleukin-1 beta levels in mouse ear tissue. " 02/01/2015 - "Second, we linked such behavioral changes to the selective increased striatal expression of interleukin-1beta (IL-1β) in a context of mild inflammation and to dopaminergic system alterations. " 10/01/2014 - "faecalis may contribute to the progression of pulpal inflammation by stimulating excessive secretion of IL-1 beta and cell death."
3.	Infection 05/01/1993 - "75% of all mammary glands treated with three doses of IL-1 beta responded to therapy by clearing the infection and 22% of the treated glands remained cured. " 10/01/1989 - "Efficacy of interleukin-1 beta against systemic Candida albicans infections in normal and immunosuppressed mice." 10/01/2004 - "Antibody neutralization studies have shown that in Pseudomonas aeruginosa corneal infection, IL-1 beta is critical to regulation of the host inflammatory response, but mechanisms remain undetermined. " 01/01/2004 - "Our study suggests that fibroblasts may be involved in the defense against infections via an IL-1 beta-mediated but not an IL-18-mediated mechanism." 06/01/2001 - "The aim of this study was to determine the effects of H pylori infection on gastric acid secretion and clarify its mechanisms with reference to interleukin 1beta (IL-1beta). "
4.	Ischemia 04/01/2004 - "In this study, we examined the cellular mechanism for ischemia-induced neovascularization using IL-1 beta knock-out (-/-) mice. " 01/01/1999 - "This study has ascertained the cellular localization and chronologic and topographic distribution of pro/mature interleukin-1beta (IL-1beta) protein 0.5, 1, 2, 6, 24, and 48 hours after ischemia by subjecting rats to permanent unilateral occlusion of the middle cerebral artery. " 09/15/2007 - "Leukocyte transmigration (but not adhesion) through mouse cremasteric venules as stimulated by interleukin 1beta (IL-1beta) or ischemia/reperfusion (I/R) injury was significantly reduced in wild-type mice treated with BV-11 and in JAM-A KO animals. " 01/01/2005 - "In addition, pre-treatment with 200 mg/kg SJ also significantly reduced ED1 and interleukin-1beta immunostaining positive cells, and apoptotic cells in ischemia-reperfusion cerebral infarct rats. " 01/01/2005 - "Interleukin-1beta (IL-1beta) is known to play a central role in ischemia-induced brain damage in rodents. "
5.	Neoplasms (Cancer) 09/01/2011 - "Interleukin 1 beta (IL1B) promoter polymorphism and cancer risk: evidence from 47 published studies." 05/07/2015 - "Remarkably, when exposed to IL-1 beta (IL-1β) inflammatory stimuli, mutp53 sustains a ready-to-be-activated in vitro and in vivo cancer cells' response through the sIL-1Ra repression. " 01/01/2014 - "Urinary and serum levels of IL-1 beta were analyzed by ELISA from a patient cohort consisting of healthy women (N = 10), women with ovarian benign disease (N = 23), women with OC (N = 32), women with other benign gynecological conditions (N = 22), and women with other gynecological cancers (N = 6). " 01/01/2012 - "When IL-1 beta signaling was blocked, tumor growth, invasion ability, and treatment resistance were attenuated. " 01/01/2012 - "Human esophageal SCC cell line, CE81T, was selected for cellular and animal experiments, in which biological changes after experimental manipulation of IL-1 beta signaling were explored, including tumor growth, invasion capacity, and the sensitivity to treatment. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Interleukin-6 (Interleukin 6)
3.	Cytokines
4.	Interleukin-1 (Interleukin 1)
5.	Interleukin-1alpha (Interleukin 1 alpha)
6.	Interleukin-8 (Interleukin 8)
7.	Messenger RNA (mRNA)
8.	Interferon-gamma (Interferon, gamma)
9.	Interleukin-10 (Interleukin 10)
10.	Dinoprostone (PGE2)

Related Therapies and Procedures

1.	Oral Administration
2.	Aftercare (After-Treatment)
3.	Drug Therapy (Chemotherapy)
4.	Heterologous Transplantation (Xenotransplantation)
5.	Microspheres (Microsphere)