Intrinsic Factor

A glycoprotein secreted by the cells of the GASTRIC GLANDS that is required for the absorption of VITAMIN B 12 (cyanocobalamin). Deficiency of intrinsic factor leads to VITAMIN B 12 DEFICIENCY and ANEMIA, PERNICIOUS.

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Networked: 387 relevant articles (8 outcomes, 24 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Tanner, Stephan M: 4 articles (10/2012 - 07/2005)
2.	Lahner, Edith: 4 articles (12/2011 - 09/2005)
3.	Annibale, Bruno: 4 articles (12/2011 - 09/2005)
4.	Antico, Antonio: 2 articles (04/2014 - 01/2012)
5.	Bizzaro, Nicola: 2 articles (04/2014 - 01/2012)
6.	Alpers, D H: 2 articles (11/2011 - 10/2000)
7.	Norman, Gary L: 2 articles (03/2010 - 08/2009)
8.	Delle Fave, Gianfranco: 2 articles (08/2009 - 09/2005)
9.	Goldenring, James R: 2 articles (06/2009 - 12/2007)
10.	Desai, H G: 2 articles (12/2007 - 04/2007)

Related Diseases

1.	Pernicious Anemia 10/01/1985 - "It is reasonable to presume that this assay is clinically useful for detection of intrinsic factor blocking antibody in the diagnosis of pernicious anemia, if false positive results due to B12 medication are excluded." 01/01/1983 - "Gastric juice in congenital pernicious anemia contains no immunoreactive intrinsic factor molecule: study of three kindreds with variable ages at presentation, including a patient first diagnosed in adulthood." 03/01/1964 - "[STUDY OF A CASE OF PERNICIOUS ANEMIA IN A CHILD WITH NORMAL "INTRINSIC FACTOR" ACTIVITY IN ITS GASTRIC JUICE]." 10/26/1963 - "[FURTHER STUDY ON INTRINSIC FACTOR-INHIBITING ACTIVITY IN THE SERUM OF PERNICIOUS ANEMIA PATIENTS]." 10/27/1962 - "[Studies on an intrinsic factor-inhibiting substance in the serum of patients with pernicious anemia]."
2.	Atrophic Gastritis 10/01/2010 - "Intrinsic factor antibody negative atrophic gastritis; is it different from pernicious anaemia?" 01/01/1983 - "The diagnosis was confirmed by demonstration of atrophic gastritis, failure of secretion of Intrinsic Factor and Schilling test. " 10/01/1975 - "No association has been found between any HL-A specificity and an increased incidence of either serum gastric parietal cell or intrinsic factor antibody compared with the overall incidence in pernicious anaemia, atrophic gastritis or in the whole series." 12/01/2015 - "Biermer disease or pernicious anemia is an autoimmune atrophic gastritis characterized by the lack of secretion of gastric intrinsic factor. " 01/01/1986 - "Functional or morphological involvement of the small intestine was seen in almost all patients with vitamin B12 deficiency but, in addition, atrophic gastritis resulting in defective secretion of intrinsic factor (pernicious anaemia) was found in 8 cases (7% of all DH patients). "
3.	Gastritis 11/01/2011 - "Ectopic expression of gastric intrinsic factor (IF) has been described in rodent models of chronic gastritis. " 11/01/2011 - "Production of ectopic gastric intrinsic factor in gastric mucosa of humans with chronic gastritis." 10/01/2010 - "Parietal cell antibody (PCA) and intrinsic factor antibody (IFA) are characteristic of autoimmune gastritis, of which IFA is more specific. " 01/01/1970 - "The secretion of intrinsic factor in patients with chronic gastritis." 05/01/1999 - "Characteristic features of type A gastritis are hyposecretion and mucosal atrophy in the fundus and body of the stomach, with absent intrinsic factor. "
4.	Steatorrhea 06/01/1977 - "Schilling tests (with intrinsic factor) improve in two patients and steatorrhea improved in all and there was significant weight gain. " 01/01/1979 - "Three patients with a bodyweight less than 75% of the idealweight died, steatorrhea (8--19 g/die), bloodsugar oscillation in the 24 h-profile (40--820 mg%) and an intrinsic-factor-non-responsive vitamin B12-malabsorption without megaloblastic anemia. "
5.	Intestinal Diseases (Diseases, Intestinal) 06/11/1977 - "This method is also shown to be a sensitive index of improved vitamin B12 absorption after treatment of small-intestinal disease and with the addition of intrinsic factor in pernicious anaemia. " 09/01/1968 - "There is no relation between histamine-stimulated intrinsic factor production and vitamin B(12) absorption in patients with small intestinal disease."

Related Drugs and Biologics

1.	Vitamin B 12 (Cyanocobalamin)
2.	Antibodies
3.	Gastrins
4.	Vitamins
5.	Antigens
6.	Pepsin A (Pepsin)
7.	Hydrochloric Acid (Hydrogen Chloride)
8.	Factor VIII (Coagulation Factor VIII)
9.	Protein S
10.	Protein C

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Massage (Reflexology)
3.	Gastrectomy
4.	Oral Administration
5.	Gastric Bypass (Roux-en-Y Gastric Bypass)