Measles: immune suppression and immune responses.

Abstract

Measles is a highly contagious viral disease that remains the leading vaccine-preventable cause of child mortality worldwide. Deaths from measles are due largely to an increased susceptibility to secondary bacterial and viral infections, attributed to a prolonged state of immune suppression. Several abnormalities of the immune system have been described, including changes in lymphocyte number and function, shifts in cytokine responses, immunomodulatory effects of interleukin-10, down regulation of interleukin-12, impaired antigen presentation, and altered interferon alpha/beta signaling pathways. Although the current vaccine is very effective, knowledge of the molecular basis of the immune responses to measles virus could contribute to the development of a safer, more immunogenic measles vaccine. However, the safety of new measles vaccines must be carefully investigated, as two measles vaccines have resulted in unintended immunologic consequences: atypical measles following administration of the formalin-inactivated measles vaccine and increased mortality in girls following administration of high-titer measles vaccines.

• Authors: William J Moss, Martin O Ota, Diane E Griffin
• Journal: The international journal of biochemistry & cell biology (Int J Biochem Cell Biol) Vol. 36 Issue 8 Pg. 1380-5 (Aug 2004) ISSN: 1357-2725 [Print] Netherlands
• PMID: 15147716 (Publication Type: Journal Article, Review)

Topics

• Humans
• Immune Tolerance
• Immunity
• Measles (complications, immunology, therapy)