Abstract | OBJECTIVE: METHODS: RESULTS: Administration of PG201 significantly suppressed the progression of CIA and inhibited the production of TNF-alpha and IL-1beta in the paws. The erosion of cartilage was dramatically reduced in mouse knees after treatment with PG201. In the serum of PG201-treated mice, the level of TIMP-2 and the ratio of TIMP-2 to MMP-2 were significantly elevated, and the level of IL-4, but not of IL-10, was increased. CONCLUSION:
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Authors | S S Shin, M Jin, H J Jung, B Kim, H Jeon, J J Choi, J M Kim, B W Cho, S H Chung, Y W Lee, Y W Song, Sunyoung Kim |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 42
Issue 5
Pg. 665-72
(May 2003)
ISSN: 1462-0324 [Print] England |
PMID | 12709543
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antirheumatic Agents
- Drugs, Chinese Herbal
- Interleukin-1
- Interleukins
- Plant Extracts
- Tissue Inhibitor of Metalloproteinases
- Tumor Necrosis Factor-alpha
- herbal extract PG201
- Ethanol
- Collagen
- Matrix Metalloproteinase 2
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Topics |
- Animals
- Antirheumatic Agents
(therapeutic use, toxicity)
- Arthritis, Experimental
(metabolism, pathology, prevention & control)
- Collagen
- Disease Progression
- Dose-Response Relationship, Drug
- Drugs, Chinese Herbal
(therapeutic use, toxicity)
- Ethanol
- Female
- Interleukin-1
(analysis)
- Interleukins
(blood)
- Male
- Matrix Metalloproteinase 2
(blood)
- Mice
- Mice, Inbred DBA
- Phytotherapy
(adverse effects)
- Plant Extracts
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Tissue Inhibitor of Metalloproteinases
(blood)
- Tumor Necrosis Factor-alpha
(analysis)
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