Tissue Inhibitor of Metalloproteinase-2

A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.

Also Known As:

Networked: 1457 relevant articles (45 outcomes, 245 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stetler-Stevenson, William G: 16 articles (10/2021 - 07/2004)
2.	Turpeenniemi-Hujanen, Taina: 13 articles (01/2013 - 01/2004)
3.	Szmitkowski, Maciej: 10 articles (04/2020 - 07/2010)
4.	Kellum, John A: 8 articles (11/2020 - 01/2014)
5.	Tanus-Santos, Jose E: 7 articles (01/2015 - 07/2008)
6.	Yang, Shun-Fa: 7 articles (09/2013 - 07/2002)
7.	Vizoso, Francisco J: 6 articles (01/2019 - 05/2008)
8.	Wei, Beiyang: 6 articles (12/2017 - 12/2004)
9.	Mroczko, Barbara: 6 articles (04/2014 - 07/2010)
10.	Jaworski, Diane M: 6 articles (04/2011 - 05/2005)

Related Diseases

1.	Neoplasms (Cancer) 03/20/2000 - "In human breast cancers, however, we show that high levels of TIMP-2 correlate with both shortened disease-free interval and overall survival. " 12/01/2006 - "In this study, we demonstrate that expression of TIMP-2 enhanced the antitumor efficacy of a replicating adenovirus in vivo, by reducing both tumor growth and angiogenesis." 01/01/2019 - "This study offers strong evidence that TIMP-2 expression in tumor tissue may play a crucial role in progression and poor prognosis in human localized and locally advanced RCC." 03/01/2014 - "MMP-9 and TIMP-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial SCC genes." 01/01/2014 - "Studies have shown that TIMP-2 has two roles in tumor invasion. "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 09/20/2020 - "Conclusion: Urinary IGFBP7 and TIMP-2 concentrations were significantly increased in patients with decompensated hepatitis B virus-related liver cirrhosis. " 05/12/2017 - "Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. " 05/12/2017 - "MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2 (P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values (P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements (P = 0.01). " 08/01/2013 - "These results suggest that faster progression of liver fibrosis could be associated with TIMP-2 -418 G homozygotes. " 05/01/2010 - "The results suggested that TIMP-2 ASON could prevent the progression of liver fibrosis in this rat model. "
3.	Carcinoma (Carcinomatosis) 05/01/2002 - "Similarly, the MMP-2 to TIMP-2 ratio also showed statistically significant difference between normal bladder tissue and bladder carcinoma (P < 0.01). " 08/01/2013 - "The present study investigates the influence of MMP-1, MMP-9 and TIMP-2 on different clinicopathologic variables and disease-free survival (DFS) of patients with prostate carcinoma. " 01/01/2002 - "Immunohistochemical studies revealed a diffuse granular distribution of MMP-2, MMP-9, and TIMP-2 in the cytoplasm of the carcinoma cells. " 02/01/1996 - "This study demonstrates cell surface binding of a synthetic MMP-2 inhibitor and provides new evidence of MMP-2 and TIMP-2 immunoreactivity in ovarian carcinomas and cell lines." 12/01/2017 - "Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients."
4.	Fibrosis (Cirrhosis) 01/01/2023 - "The aim of this study was to investigate Metalloproteinase-2 (MMP-2) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) activities in a homogeneous group of FBSS patients with epidural fibrosis in comparison to its activity in patients with surgically treated DH. " 01/01/2021 - "The imbalance between MMP-2 and TIMP-2 may prove tissue fibrosis as a response to congenital peritoneal adhesions." 09/20/2020 - "Urinary IGFBP7, TIMP-2 and IGFBP7×TIMP-2 in cirrhosis-AKI group or cirrhosis-non-AKI group were significantly higher than those of the normal control group (P < 0.01). " 09/20/2020 - "Results: Urinary IGFBP7, IGFBP7 with TIMP-2 (IGFBP7×TIMP-2) in cirrhosis-AKI group (n = 19) were equally higher than that of the cirrhosis-non-AKI group (P < 0.05). " 09/01/2020 - "Conclusion: XC could reduce the expression of TGF-β and smad2/3 phosphorylation, down-regulate the expression of TIMP-2, which would inhibit the formation of myocardial fibrosis in CIH rats, and improve the myocardial function of CIH rats. "
5.	Thyroid Neoplasms (Thyroid Cancer) 03/01/2014 - "Previous studies analyzing the expression of MMP-9 and TIMP-2 in medullary thyroid carcinoma (MTC) are scarce. " 03/01/2014 - "Reduced tissue inhibitor of metalloproteinase-2 expression is associated with advanced medullary thyroid carcinoma." 06/01/2004 - "Serum MMP-2 and TIMP-2 concentrations in patients with thyroid cancer did not significantly correlate with the clinical staging of thyroid cancer." 06/01/2004 - "MMP-2 and its tissue inhibitor TIMP-2 apparently play a significant role in the pathogenesis of thyroid cancer. " 06/01/2004 - "The aim of the study was to evaluate the concentration of MMP-2 and TIMP-2 in blood serum of patients with benign and malignant thyroid tumours and the effect of surgical treatment on these parameters in the postoperative period as well as assessment whether to MMP-2 and TIMP-2 serum concentration in patients with thyroid cancer positively correlates with the clinical staging classification of the International Union Against Cancer (UICC). "

Related Drugs and Biologics

1.	Tissue Inhibitor of Metalloproteinase-1
2.	Messenger RNA (mRNA)
3.	Matrix Metalloproteinases (MMPs)
4.	Matrix Metalloproteinase 2 (Gelatinase A)
5.	Proteins (Proteins, Gene)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Tissue Inhibitor of Metalloproteinases
8.	Matrix Metalloproteinase 14 (MT1-MMP)
9.	Collagen
10.	Collagen Type I (Type I Collagen)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Therapeutics
3.	Ligation
4.	Lasers (Laser)
5.	Chemoradiotherapy