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Matrix Metalloproteinase 2 (Gelatinase A)

Subscribe to New Research on Matrix Metalloproteinase 2

A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.

Also Known As:

Gelatinase A; 72-kDa Gelatinase; 72-kDa Type IV Collagenase; MMP-2 Metalloproteinase; MMP2 Metalloproteinase; Matrix Metalloproteinase-2; 72 kDa Gelatinase; 72 kDa Type IV Collagenase; Gelatinase, 72-kDa; MMP 2 Metalloproteinase; Metalloproteinase 2, Matrix; Metalloproteinase, MMP-2; Metalloproteinase, MMP2

Networked: 2215 relevant articles (36 outcomes, 269 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Peptide Hydrolases: 7577
      - Metalloproteases: 2318
        Metalloendopeptidases: 49
        Matrix Metalloproteinases: 8496
        Secreted Matrix Metalloproteinases: 9
        Matrix Metalloproteinase 2: 2215
        human Col-1 peptide
        human MMP2 protein
        mouse Mmp2 protein
        rat Mmp2 protein
        Collagenases: 2958
        Matrix Metalloproteinase 2: 2215
        human Col-1 peptide
        human MMP2 protein
        mouse Mmp2 protein
        rat Mmp2 protein
        Gelatinases: 1831
        Matrix Metalloproteinase 2: 2215
        human Col-1 peptide
        human MMP2 protein
        mouse Mmp2 protein
        rat Mmp2 protein
      - Endopeptidases: 212
        Metalloendopeptidases: 49
        Matrix Metalloproteinases: 8496
        Secreted Matrix Metalloproteinases: 9
        Matrix Metalloproteinase 2: 2215
        human Col-1 peptide
        human MMP2 protein
        mouse Mmp2 protein
        rat Mmp2 protein
        Collagenases: 2958
        Matrix Metalloproteinase 2: 2215
        human Col-1 peptide
        human MMP2 protein
        mouse Mmp2 protein
        rat Mmp2 protein
        Gelatinases: 1831
        Matrix Metalloproteinase 2: 2215
        human Col-1 peptide
        human MMP2 protein
        mouse Mmp2 protein
        rat Mmp2 protein

Experts

1.	Yang, Shun-Fa: 28 articles (10/2015 - 02/2002)
2.	Lovett, David H: 22 articles (01/2015 - 07/2002)
3.	Hsieh, Yih-Shou: 22 articles (01/2013 - 02/2002)
4.	Chung, Jing-Gung: 19 articles (07/2015 - 03/2006)
5.	Schulz, Richard: 15 articles (11/2013 - 08/2002)
6.	Sawicki, Grzegorz: 13 articles (01/2015 - 09/2002)
7.	Yang, Jai-Sing: 13 articles (01/2014 - 11/2009)
8.	Chu, Shu-Chen: 13 articles (09/2012 - 01/2003)
9.	Turpeenniemi-Hujanen, Taina: 9 articles (08/2011 - 01/2003)
10.	Bar-Eli, Menashe: 9 articles (09/2009 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2015 - "The aim of this study was to examine the tumor therapy, targeting effects and side effects of tumor-targeting rhTNF-α fusion protein mediated by matrix metalloproteinase-2 in an animal model in order to provide experimental data for future development of drugs. " 10/01/2013 - "Epithelial expression of extracellular matrix metalloproteinase inducer/CD147 and matrix metalloproteinase-2 in neoplasms and precursor lesions derived from cutaneous squamous cells: An immunohistochemical study." 01/02/2013 - "A previous study demonstrated that SIP-SII, a sulfated Sepiella maindroni ink polysaccharide, suppressed the invasion and migration of cancer cells via the inhibition of the proteolytic activity of matrix metalloproteinase-2 (MMP-2). " 03/01/2008 - "To study the expression of matrix metalloproteinase-2 (MMP-2) in cancer of uterine cervix and correlate its expression with clinicopathological parameters, recurrence and survival of patients. " 03/01/2008 - "Clinical significance of matrix metalloproteinase-2 in cancer of uterine cervix: a semiquantitative study of immunoreactivities using tissue array."
2.	Fibrosis (Cirrhosis) 07/01/2013 - "These changes were associated with altered myocardial substrate utilization and improved mitochondrial capacity and efficiency, as well as reduced oxidative stress, fibrosis, and intracellular matrix metalloproteinase 2 content. " 11/01/2015 - "Plasma levels of matrix metalloproteinase-2 and -9 in male and female patients with cirrhosis of different aetiologies." 09/01/2015 - "rhACE2 effectively antagonized Ang II-mediated myocardial fibrosis which was dependent on the action of Ang 1-7. Myocardial oxidative stress and matrix metalloproteinase 2 activity was further increased by Ang 1-7 inhibition even in the presence of rhACE2. " 03/15/2014 - "Consistent with attenuated fibrosis, both MSC therapy and sFRP2 antibody administration significantly increased the activity of myocardial matrix metalloproteinase-2. " 09/01/2013 - "We evaluated the characteristics of DCM by serial echocardiography, electron microscopy, histopathologic analysis of cardiomyocyte fibrosis area, and Western blot analysis of matrix metalloproteinase-2 (MMP-2) and MMP-9 expression. "
3.	Melanoma (Melanoma, Malignant) 10/01/2000 - "Our study demonstrates that the presence of activated matrix metalloproteinase-2 correlates with expression of alpha(v)beta3 in human melanoma cells both in vitro and in vivo, and also in fresh human melanoma lesions. " 05/01/1999 - "In this study, the expression of matrix metalloproteinase-2 (MMP-2) was characterized immunohistochemically in 29 human uveal melanomas. " 03/01/1995 - "In this study we demonstrate that inhibition of endogenous gelatinase A activity in A2058 human melanoma cells results in enhanced cellular adhesion. " 10/20/2015 - "GLUT1 suppressed melanoma cells revealed significantly reduced proliferation, apoptosis resistance, migratory activity and matrix metalloproteinase 2 (MMP2) expression. " 08/01/2015 - "In addition, the correlation between matrix metalloproteinase 2 (MMP2) and NRP1 expression in patients with melanoma was analyzed. "
4.	Inflammation 12/01/2014 - "Increased levels of the matrix metalloproteinases-2 and -9 (also referred to gelatinase-A and -B, respectively) can be detected in intestinal inflammation. " 05/26/2014 - "These cells respond to APC by upregulating proliferation, migration and matrix metalloproteinase-2 activity and inhibiting apoptosis/inflammation leading to a wound healing phenotype. " 05/01/2009 - "In addition, the expression and activity of matrix metalloproteinase-2 and 9 that play an important role in chronic inflammation were decreased in dose-dependent manner in the presence of IO extract in HT1080 cells. " 04/15/2009 - "Matrix metalloproteinase-2 (MMP-2) plays important roles in inflammation and immunity besides its basic role in degrading and remodelling extracellular matrix (ECM). " 11/08/2011 - "The present study investigated whether gene deletion of matrix metalloproteinase-2 influences cardiac inflammation and function in murine coxsackievirus B3 (CVB3)-induced myocarditis. "
5.	Liver Cirrhosis (Hepatic Cirrhosis) 10/01/2001 - "The aim of this study was to investigate whether both matrix metalloproteinase-2 (MMP-2) and membrane type 1 MMP (MT1-MMP) participate in the spontaneous resolution of liver fibrosis. " 01/01/2013 - "Serum apoptotic cytokeratine 18 neoepitope M30 (CK-18 M30) and matrix metalloproteinase 2 (MMP-2) have been popular markers for detecting liver fibrosis in recent years. " 10/01/2004 - "Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis." 03/01/2003 - "[Expression of matrix metalloproteinase-2 in rats with liver fibrosis]." 12/01/1997 - "We have previously reported increased expression of matrix metalloproteinase-2 (MMP-2) using a rat model of liver fibrosis. "

Related Drugs and Biologics

1.	Collagen
2.	Messenger RNA (mRNA)
3.	Matrix Metalloproteinase 9 (Gelatinase B)
4.	Tissue Inhibitor of Metalloproteinase-1
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Tissue Inhibitor of Metalloproteinase-2
7.	Proteins (Proteins, Gene)
8.	Doxorubicin (Adriamycin)
9.	Thrombospondins
10.	Gelatinases

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Debridement
3.	Aftercare (After-Treatment)
4.	Balloon Angioplasty
5.	Ligation