Abstract | BACKGROUND:
Endothelin (ET) and angiotensin II (Ang II) are vasoactive/trophic peptides that may contribute to the progression of diabetic nephropathy. The transgenic (mRen-2)27 rat exhibits overexpression of Ang II at sites of normal physiological expression. Unlike other rat strains, the streptozotocin-induced diabetic Ren-2 rat develops progressive renal pathology associated with a declining glomerular filtration rate (GFR) and provides a convenient model to evaluate the role of these vasoactive peptides in the nephropathic process. METHODS AND RESULTS: CONCLUSIONS: Despite producing normotension, severe diabetic renal pathology was not prevented by bosentan, suggesting dissociation of ET, albuminuria, and hypertension from the structural injury in this diabetic model. The beneficial effects afforded by valsartan therapy strengthen the importance of the local renin-angiotensin system in mediating progressive diabetic renal injury.
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Authors | D J Kelly, S L Skinner, R E Gilbert, A J Cox, M E Cooper, J L Wilkinson-Berka |
Journal | Kidney international
(Kidney Int)
Vol. 57
Issue 5
Pg. 1882-94
(May 2000)
ISSN: 0085-2538 [Print] United States |
PMID | 10792607
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin Receptor Antagonists
- RNA, Messenger
- Receptor, Angiotensin, Type 1
- Receptor, Angiotensin, Type 2
- Transforming Growth Factor beta
- Streptozocin
- Collagen
- Renin
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Topics |
- Angiotensin Receptor Antagonists
- Animals
- Animals, Genetically Modified
- Blood Pressure
(drug effects)
- Body Weight
- Collagen
(genetics)
- Diabetes Mellitus, Experimental
(drug therapy, metabolism, pathology)
- Diabetic Nephropathies
(drug therapy, metabolism, pathology)
- Female
- Immunohistochemistry
- RNA, Messenger
(analysis)
- Rats
- Receptor, Angiotensin, Type 1
- Receptor, Angiotensin, Type 2
- Renin
(genetics)
- Streptozocin
- Transforming Growth Factor beta
(physiology)
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