Cryptoxanthins

Mono-hydroxylated xanthophylls formed from the hydroxylation of BETA-CAROTENE. Isomers include: beta-cryptoxanthin, alpha-cryptoxanthin, and zeinoxanthin. The alpha- and beta-cryptoxanthin are provitamin A precursors.

Also Known As:

Networked: 161 relevant articles (17 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sugiura, Minoru: 12 articles (09/2019 - 01/2012)
2.	Wang, Xiang-Dong: 7 articles (04/2022 - 08/2011)
3.	Ogawa, Kazunori: 7 articles (01/2016 - 01/2012)
4.	Liu, Chun: 6 articles (04/2022 - 08/2011)
5.	Ota, Tsuguhito: 6 articles (01/2021 - 01/2014)
6.	Wilkens, Lynne R: 5 articles (03/2020 - 01/2000)
7.	Ni, Yinhua: 5 articles (10/2017 - 01/2014)
8.	Franke, Adrian A: 4 articles (03/2020 - 01/2000)
9.	Hu, Kang-Quan: 4 articles (01/2020 - 04/2013)
10.	Chen, Yu-Ming: 4 articles (03/2019 - 05/2014)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 12/26/2021 - "β-Cryptoxanthin has recently gained attention for its risk-reducing effects on lifestyle-related diseases, especially on non-alcoholic fatty liver disease (NAFLD), from epidemiological, interventional, and mechanistic studies. " 10/20/2020 - "A hypocaloric HP-diet supplemented with β-cryptoxanthin safely and efficaciously improves NAFLD. " 10/20/2020 - "Ninety-two Iranian NAFLD outpatients were recruited for this 12-week, single-center, parallel-group, double-blind RCT and randomized into 4 arms (n = 23): HP-diet and β-cryptoxanthin (hypocaloric HP-diet + β-cryptoxanthin), HP-diet (hypocaloric HP-diet + placebo), β-cryptoxanthin (standard hypocaloric diet + β-cryptoxanthin), and control (standard hypocaloric diet + placebo). " 10/20/2020 - "Safety and efficacy assessment of a hypocaloric HP-diet supplemented with β-cryptoxanthin in NAFLD. " 01/01/2014 - "β-Cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice."
2.	Insulin Resistance 09/01/2017 - "β-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-κB and Nrf2 pathways in insulin resistance induced by high-fat diet in rodents." 09/01/2017 - "The aim of this experiment was to determine the effects of β-cryptoxanthin (BCX) on the cardiometabolic health risk factors and NF-κB and Nrf2 pathway in insulin resistance induced by high-fat diet (HFD) in rodents. " 03/01/2015 - "In conclusion, β-cryptoxanthin prevents and reverses insulin resistance and steatohepatitis, at least in part, through an M2-dominant shift in macrophages/Kupffer cells in a lipotoxic model of NASH." 01/01/2014 - "Consumption of β-cryptoxanthin possibly prevents nonalcoholic steatohepatitis (NASH), which is suggested to be caused by insulin resistance and oxidative stress from nonalcoholic fatty liver disease. " 01/01/2014 - "Recent nutritional epidemiological surveys showed that serum β-cryptoxanthin inversely associates with the risks for insulin resistance and liver dysfunction. "
3.	Inflammation (Inflammations) 01/01/2016 - "Anti-inflammatory potential of β-cryptoxanthin against LPS-induced inflammation in mouse Sertoli cells." 03/01/2015 - "Moreover, β-cryptoxanthin reversed steatosis, inflammation, and fibrosis progression in preexisting NASH in mice. " 01/01/2014 - "Thus, β-cryptoxanthin suppresses inflammation and the resulting fibrosis probably by primarily suppressing the increase and activation of macrophages and other immune cells. " 02/01/2011 - "Neighborhood Z-scores were positively associated with serum α-carotene (P = 0.0006), β-carotene (P = 0.07), β-cryptoxanthin (P = 0.03), and lutein+zeaxanthin (P = 0.004) after adjusting for age, race, BMI, smoking, inflammation, and season. " 01/01/2020 - "The efficacy of β-cryptoxanthin (BCX), a high-protein diet (HPD), or both in reducing oxidative stress and inflammation in nonalcoholic fatty liver disease (NAFLD) has never been examined within a randomized controlled trial (RCT). "
4.	Breast Neoplasms (Breast Cancer) 01/14/2016 - "However, no significant association was found between serum β-cryptoxanthin and the risk for breast cancer. " 01/01/2014 - "Plasma β-cryptoxanthin concentration was inversely associated with breast cancer risk (OR = 0.83, 95% CI = 0.71-0.96, Ptrend = 0.02). " 03/01/2012 - "Although the pooled RRs for quintile 5 for β-cryptoxanthin were not significant, inverse trends were observed for ER- and ER+ breast cancer (P-trend ≤ 0.05). " 01/01/2016 - "The following new findings were identified: α-Carotene and β-cryptoxanthin have protective effects on overall breast cancer. " 01/01/2014 - "This prospective study suggests an inverse association between plasma concentrations of β-cryptoxanthin and both overall and breast cancer risk, and an inverse association between β-carotene and overall cancer risk. "
5.	Infarction (Infarctions) 08/01/2022 - "The results indicated that β-cryptoxanthin decreases infarct size and ameliorates signs of pathological histology in MIRI. " 10/01/2017 - "Although astaxanthin and vitamin E exhibited similar efficacy with respect to cardioprotection, β-cryptoxanthin exhibited greater efficacy than its counterparts, as it reduced infarct sizes by 60%. " 10/01/2017 - "We hypothesized that acute treatment with β-cryptoxanthin and astaxanthin causes similar reductions in the sizes of cardiac infarcts caused by ischemia-reperfusion (I/R) injury by attenuating oxidative stress and cardiac mitochondrial dysfunction. " 10/01/2017 - "Acute β-cryptoxanthin treatment exhibits greater cardioprotective efficacy against I/R injury than astaxanthin and vitamin E by reducing infarct sizes and attenuating apoptosis, oxidative stress, and mitochondrial dysfunction."

Related Drugs and Biologics

1.	Carotenoids (Carotene)
2.	Lycopene
3.	Lutein
4.	Zeaxanthins
5.	astaxanthine (astaxanthin)
6.	Vitamin A (Retinol)
7.	Antioxidants
8.	Tocopherols (Tocopherol)
9.	Vitamin E
10.	Tea

Related Therapies and Procedures

1.	High-Protein Diet
2.	Therapeutics
3.	Chemoprevention
4.	Oral Administration
5.	Mediterranean Diet