Inducible T-Cell Co-Stimulator Protein

A costimulatory receptor that is specific for INDUCIBLE T-CELL CO-STIMULATOR LIGAND. The receptor is associated with a diverse array of immunologically-related effects including the increased synthesis of INTERLEUKIN 10 in REGULATORY T-LYMPHOCYTES and the induction of PERIPHERAL TOLERANCE.

Also Known As:

Activation-Inducible Lymphocyte Immunomediatory Molecule; Antigens, CD278; CD278 Antigen; ICOS Inducible T-Cell Co-Stimulator; Inducible Co-Stimulator (ICOS); Inducible Costimulator (ICOS); Inducible T-Cell Co-Stimulator; Activation Inducible Lymphocyte Immunomediatory Molecule; Antigen, CD278; CD278 Antigens; Co-Stimulator, Inducible T-Cell; ICOS Inducible T Cell Co Stimulator; Inducible T Cell Co Stimulator; Inducible T Cell Co Stimulator Protein; T-Cell Co-Stimulator, Inducible

Networked: 96 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	He, Min: 3 articles (01/2022 - 03/2009)
2.	Grimbacher, Bodo: 3 articles (01/2017 - 04/2006)
3.	Sharpe, Arlene H: 3 articles (01/2016 - 04/2005)
4.	Wang, Jian: 3 articles (10/2011 - 10/2005)
5.	Kroczek, Richard A: 3 articles (08/2010 - 03/2004)
6.	Coyle, Anthony J: 3 articles (07/2004 - 06/2003)
7.	Dianzani, Umberto: 2 articles (01/2022 - 01/2014)
8.	Fan, Martin: 2 articles (01/2022 - 01/2020)
9.	Hanson, Amanda: 2 articles (01/2022 - 01/2020)
10.	Harvey, Christopher J: 2 articles (01/2022 - 01/2020)

Related Diseases

1.	Neoplasms (Cancer) 03/15/2021 - "In this study, we employed multiplex immunofluorescence to investigate the intratumoral expression of the co-stimulatory receptor inducible T-cell co-stimulator (ICOS), the inhibitory receptors lymphocyte-activation gene 3 (LAG-3), programmed death 1 (PD-1), and V-domain immunoglobulin suppressor of T cell activation (VISTA) by tumor-infiltrating T cells (CD3) in a cohort of 69 patients with resected PDAC. " 01/01/2022 - "Inducible co-stimulator (ICOS), an immune costimulatory molecule, has been found to play an essential role across various malignancies. " 01/01/2022 - "Importantly, as compared with PARhigh controls, the PARP1KO LLC tumors exhibited signs of T cell activation in the immune infiltrate such as higher inducible costimulator (ICOS) expression and lower PD-1 expression on CTLs. " 01/01/2022 - "Inducible co-stimulator (ICOS), an important co-stimulatory receptor on effector T cells (Teffs), may also contribute to tumor growth due to its high expression on regulatory T cells (Tregs). " 01/01/2021 - "The Treg accumulating in the tumors expressed inducible T-cell co-stimulator (ICOS), OX-40, and CD39, indicating that they were effector Treg (eTreg). "
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2023 - "This study aimed to investigate the expression of inducible T-cell co-stimulator (ICOS) and its ligand (ICOSLG), along with their association with clinicopathological features and influence on the immune profile in colorectal cancer (CRC). "
3.	Stomach Neoplasms (Stomach Cancer) 02/01/2014 - "In this study, we investigated pDCs and pDC-induced inducible costimulator (ICOS)(+) Treg populations in peripheral blood from gastric cancer (GC) patients and healthy donors by flow cytometry. "
4.	Malaria 01/01/2016 - "Mechanistic studies in mice showed that PD-L2 was indispensable for establishing effective CD4(+) T cell immunity against malaria, because it not only inhibited PD-L1 to PD-1 activity but also increased CD3 and inducible co-stimulator (ICOS) expression on T cells. "
5.	Pulmonary Hypertension 03/13/2022 - "Pulmonary hypertension (PH) is a life-threatening complication of connective tissue diseases (CTD); in this study, we aimed at investigating the potential role of inducible co-stimulator (ICOS) and its ligand (ICOS-L) as biomarkers of PH in CTD. "

Related Drugs and Biologics

1.	Ligands
2.	Immunoglobulins (Immunoglobulin)
3.	CTLA-4 Antigen
4.	Biomarkers (Surrogate Marker)
5.	Nivolumab
6.	Cytokines
7.	Proteins (Proteins, Gene)
8.	CD40 Ligand (CD40L)
9.	Chemokine Receptors
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1.	Immunotherapy
2.	Immunomodulation
3.	Cell Transplantation
4.	Therapeutics