Lipoprotein(a)

A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.

Also Known As:

Networked: 2561 relevant articles (33 outcomes, 319 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tsimikas, Sotirios: 27 articles (12/2015 - 09/2004)
2.	Marcovina, Santica M: 26 articles (12/2015 - 03/2002)
3.	Koschinsky, Marlys L: 23 articles (12/2015 - 06/2003)
4.	Witztum, Joseph L: 17 articles (10/2015 - 09/2004)
5.	Kronenberg, Florian: 16 articles (10/2015 - 01/2003)
6.	Lippi, Giuseppe: 14 articles (01/2015 - 02/2003)
7.	Nordestgaard, Børge G: 13 articles (09/2015 - 11/2004)
8.	Boffa, Michael B: 10 articles (12/2015 - 06/2003)
9.	Kamstrup, Pia R: 10 articles (07/2015 - 01/2008)
10.	Tselepis, Alexandros D: 10 articles (08/2014 - 04/2003)

Related Diseases

1.	Coronary Disease (Coronary Heart Disease) 07/01/1995 - "To determine the efficacy of high-dose ascorbate supplementation in lowering lipoprotein(a) [Lp(a)] levels in patients with premature coronary heart disease (CHD). " 10/01/2013 - "Recent genetic studies have put the spotlight back onto lipoprotein(a) [Lp(a)] as a causal risk factor for coronary heart disease. " 05/01/2013 - "Lipoprotein (a) has been identified as an independent risk factor for coronary heart disease, and its elevation in PCOS patients has been consistently reported in diverse studies including non-obese Korean population. " 02/01/2011 - "Genetic studies have identified 2 single-nucleotide polymorphisms (SNPs) at the LPA locus (rs3798220 and rs10455872) that are strongly and independently related to lipoprotein(a) levels and to coronary disease risk, but their relevance for other atherothrombotic disease is uncertain. " 09/01/2009 - "The aim of this review is to put the research of lipoprotein(a) [Lp(a)] into context with the recent advances in genetic studies and risk assessment of coronary heart disease (CHD). "
2.	Coronary Artery Disease (Coronary Atherosclerosis) 07/01/2015 - "The objective of the study was to investigate the usefulness of serum lipoprotein(a) level in predicting the severity of new on-set coronary artery disease in type 2 diabetics. " 02/18/2014 - "The purpose of this study was to assess the prognostic utility of lipoprotein(a) [Lp(a)] in individuals with coronary artery disease (CAD). " 01/01/2011 - "The present study aimed to investigate the relationship between the severity of coronary artery disease (CAD) and level of Lipoprotein (LP)(a). " 03/01/2009 - "To study lipoprotein(a) [Lp(a)] levels in Saudi patients with angiographically defined coronary artery disease and to see its relationship with its severity and diffuseness. " 09/01/2008 - "Most but not all studies in children, adolescents and young adults with a family history of coronary artery disease have reported an increase in lipoprotein(a) (Lp(a)) concentrations. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 10/01/1994 - "Our understanding of the pathophysiological role of lipoprotein (a) in cardiovascular disease and its clinical importance has improved, but there are still gaps in our knowledge and analytical performance that hinder the appropriate management of patients. " 05/01/2015 - "Robust epidemiologic and genetic studies have solidified the role of lipoprotein (a) [Lp(a)] as an independent and causal risk factor for cardiovascular disease. " 01/01/2015 - "Moreover, lipoprotein a [Lp(a)], another lipid parameter independently associated with cardiovascular diseases, appears not to have been addressed at all in studies of lung function at the population level. " 09/02/2014 - "Recent studies showed that lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular disease (CVD). " 12/01/2012 - "Recent epidemiological and genetic studies have suggested that lipoprotein (a) [Lp(a)] is a causal mediator of cardiovascular disease (CVD). "
4.	Nephrotic Syndrome (Syndrome, Nephrotic) 01/01/2006 - "Recently published data suggest that plasma lipoprotein(a) levels may affect the efficacy of statin therapy in patients with nephrotic syndrome. " 10/01/1999 - "We studied the plasma lipoprotein (a)[Lp(a)] levels in 31 children with minimal lesion nephrotic syndrome (MLNS) in both stages of acute NS and remission. " 01/01/1991 - "A study of the clinical significance of lipoprotein (a) in nephrotic syndrome." 01/01/2012 - "The level of native and oxidized lipoprotein(a) in children with nephrotic syndrome." 07/01/2004 - "Patients with nephrotic syndrome have the highest lipoprotein(a) [Lp(a)] concentrations known. "
5.	Atherosclerosis 02/01/2015 - "Development of lipoprotein(a) siRNAs for mechanism of action studies in non-human primate models of atherosclerosis." 01/01/2013 - "During the past few decades, compelling pieces of evidence from clinical trials and meta-analyses consistently illustrate that lipoprotein(a) (Lp(a)) is a significant risk factor for atherosclerosis and CVD due to its proatherogenic and prothrombotic features. " 04/01/2011 - "Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study." 12/29/2009 - "The role of lipoprotein (a) (Lp(a)) in atherogenesis has been previously demonstrated in several trials reporting various and sometimes contradictory findings. " 08/01/2003 - "Plasma lipoprotein (a) [Lp(a)] has been shown to be a risk factor for atherosclerosis in numerous studies. "

Related Drugs and Biologics

1.	Lipoproteins (Lipoprotein)
2.	Cholesterol
3.	Triglycerides (Triacylglycerol)
4.	HDL Cholesterol
5.	LDL Cholesterol
6.	Fibrinogen (Factor I)
7.	Insulin (Novolin)
8.	Lipids
9.	Homocysteine
10.	C-Reactive Protein

Related Therapies and Procedures

1.	Blood Component Removal (Apheresis)
2.	Electroacupuncture
3.	Renal Dialysis (Hemodialysis)
4.	Peritoneal Dialysis
5.	Continuous Ambulatory Peritoneal Dialysis (CAPD)