Metoprolol (Toprol-XL)

A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.

Also Known As:

Toprol-XL; Lopressor; Seloken; Beloc-Duriles; Betaloc; Betaloc-Astra; Betalok; CGP-2175; H 93-26; Metoprolol CR-XL; Metoprolol Succinate; Metoprolol Tartrate; Spesicor; Spesikor; Toprol; Beloc Duriles; Betaloc Astra; CGP 2175; CGP2175; H 93 26; H 9326; Metoprolol CR XL; Toprol XL; 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-

Networked: 2892 relevant articles (336 outcomes, 785 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 140
- Amines: 4925
  - Amino Alcohols: 20
    - Propanolamines: 4
      - Phenoxypropanolamines: 1
        Metoprolol: 2892
        H 87-07: 4
        alpha-hydroxymetoprolol: 3
        logroton: 2
        O-desmethyl metoprolol: 1
        1'-fluorometoprolol
        3-(4-(1-hydroxy-2-methoxyethyl)phenoxy)-1-(isopropylamino)-2-propanol
        4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid
        H117-04
        O-demethylmetoprolol
- Alcohols: 610
  - Amino Alcohols: 20
    - Propanolamines: 4
      - Phenoxypropanolamines: 1
        Metoprolol: 2892
        H 87-07: 4
        alpha-hydroxymetoprolol: 3
        logroton: 2
        O-desmethyl metoprolol: 1
        1'-fluorometoprolol
        3-(4-(1-hydroxy-2-methoxyethyl)phenoxy)-1-(isopropylamino)-2-propanol
        4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid
        H117-04
        O-demethylmetoprolol
  - Propanols: 3
    - Propanolamines: 4
      - Phenoxypropanolamines: 1
        Metoprolol: 2892
        H 87-07: 4
        alpha-hydroxymetoprolol: 3
        logroton: 2
        O-desmethyl metoprolol: 1
        1'-fluorometoprolol
        3-(4-(1-hydroxy-2-methoxyethyl)phenoxy)-1-(isopropylamino)-2-propanol
        4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid
        H117-04
        O-demethylmetoprolol

Experts

1.	Torp-Pedersen, Christian: 22 articles (01/2021 - 06/2002)
2.	Metra, Marco: 17 articles (11/2007 - 02/2002)
3.	Swedberg, Karl: 16 articles (01/2015 - 06/2002)
4.	Pizarro, Gonzalo: 15 articles (10/2021 - 10/2012)
5.	Fuster, Valentin: 15 articles (01/2021 - 06/2007)
6.	Cleland, John G F: 15 articles (09/2017 - 06/2002)
7.	Wikstrand, John: 15 articles (05/2009 - 02/2002)
8.	Ibanez, Borja: 14 articles (01/2021 - 06/2007)
9.	Du, Junbao: 13 articles (01/2023 - 04/2008)
10.	Komajda, Michel: 13 articles (01/2015 - 06/2002)

Related Diseases

1.	Heart Failure 06/01/1999 - "Although metoprolol has been proven to be beneficial in the majority of patients with heart failure, a subset of the remaining patients shows long-term survival without satisfactory clinical improvement. " 03/08/2000 - "In this study of patients with symptomatic heartfailure, metoprolol CR/XL improved survival, reduced the need for hospitalizations due to worsening heart failure, improved NYHA functional class, and had beneficial effects on patient well-being." 12/01/1993 - "beta-Blockers, especially metoprolol, appear beneficial in some patients with heart failure, possibly related to their reduction in sympathetic nervous activity and restoration of beta-receptor population, with resultant improved contractile performance, enhanced myocardial relaxation, and overall increase in cardiac efficiency. " 09/01/2000 - "Although limited data indicate that metoprolol CR/XL is effective in patients with severe (NYHA functional class IV) chronic heart failure, more data are needed to confirm these findings. " 09/01/2000 - "Data from small numbers of patients with severe (NYHA functional class IV) heart failure indicate that metoprolol CR/XL is effective in this subset of patients. "
2.	Hypertension (High Blood Pressure) 05/01/2009 - "Although studies have shown extended release Metoprolol to be a safe and effective treatment in children with established hypertension, to the best of our knowledge, it has not been studied in a pediatric emergency setting." 06/01/1996 - "Multivariate analysis identified a group of patients with a history of mild hypertension (blood pressure between 140/90 and 170/100 mmHg) and significantly higher probability of improvement with longterm metoprolol (odds ratio [OR], 2.22; 95% confidence interval, 1.25-3.94; P = .007). " 02/01/2007 - "These data indicate that ER metoprolol is an effective and well-tolerated treatment for hypertension in children." 03/01/1992 - "Thus, controlled release metoprolol formulations offer the potential to maximise the confirmed benefits of this agent in the management of hypertension and angina, by maintaining clinically effective plasma concentrations within a narrow therapeutic range over a 24-hour dose interval." 09/01/1984 - "Metoprolol, a beta 1-adrenergic blocking agent, has been found effective in the treatment of hypertension. "
3.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 02/01/2001 - "In idiopathic dilated cardiomyopathy, the more significant improvement in symptoms and left ventricular function and size, that is observed following treatment using metoprolol, translates into a better outcome. " 05/01/1994 - "Metoprolol improved hemodynamic status in patients with dilated cardiomyopathy at rest and had a more pronounced effect during exercise. " 12/04/1997 - "Improvement in symptom score was reported in the Metoprolol in Dilated Cardiomyopathy (MDC) trial far patients treated with metoprolol. " 09/01/1985 - "Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: a double-blind, randomized, placebo-controlled trial." 01/01/1995 - "Predictors of systolic and diastolic improvement in patients with dilated cardiomyopathy treated with metoprolol."
4.	Myocardial Infarction 09/01/1987 - "These data demonstrate that beta-blockade with metoprolol is effective in controlling systolic blood pressure and heart rate both intraoperatively and postoperatively in patients undergoing repair of AAA and can significantly reduce the incidence of perioperative myocardial infarction and arrhythmias." 06/07/1986 - "Aside from bringing an improved quality of life after myocardial infarction, metoprolol may add up to one month to life expectancy for three years of treatment." 11/01/2018 - "This study observed the effects of early intravenous low-doses of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction (MI) dogs. " 03/01/2015 - "This is a prespecified subgroup analysis of the Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction trial population, who all eventually received oral metoprolol within 12 to 24 hours. " 03/01/2015 - "Efficacy and safety of out-of-hospital intravenous metoprolol administration in anterior ST-segment elevation acute myocardial infarction: insights from the METOCARD-CNIC trial."
5.	Migraine Disorders (Migraine) 09/01/2007 - "Metoprolol was proven to be effective in migraine prophylaxis in clinical trials, but its mechanism of action has not been clarified yet. " 09/01/2007 - "After 3 months, a significant reduction of migraine frequency, duration and intensity was demonstrated for the metoprolol compared with the placebo group. " 02/01/1991 - "A significant improvement was noted in 54.4% of patients with migraine during treatment with metoprolol. " 03/01/2001 - "The findings from this trial show that metoprolol is superior to ASA for migraine prophylaxis but has more side-effects. " 11/01/2006 - "In a randomized controlled multicenter trial extending over 24 weeks, we investigated whether acupuncture is as effective and safe as metoprolol in the prophylactic treatment of migraine under conditions similar to routine care. "

Related Drugs and Biologics

1.	Carvedilol (Coreg)
2.	Propranolol (Inderal)
3.	Atenolol (Tenormin)
4.	Nebivolol
5.	Antihypertensive Agents (Antihypertensives)
6.	Bisoprolol (Concor)
7.	Diltiazem (Cardizem)
8.	Metoprolol (Toprol-XL)
9.	Verapamil (Calan)
10.	Ivabradine

Related Therapies and Procedures

1.	Therapeutics
2.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
3.	Oral Administration
4.	Drug Therapy (Chemotherapy)
5.	Electric Countershock (Cardioversion)