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Metoprolol (Lopressor)

A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.

Also Known As:

Lopressor; Seloken; AstraZeneca Brand of Metaoprolol Tartrate; AstraZeneca Brand of Seloken; Beloc-Duriles; Betaloc; Betaloc-Astra; Betalok; CGP-2175; H 93-26; Leiras Brand of Metoprolol Succinate or Metoprolol Tartrate; Metoprolol Tartrate; Novartis Brand of Metprolol Tartrate; Spesicor; Spesikor; Beloc Duriles; BelocDuriles; Betaloc Astra; BetalocAstra; CGP 2175; CGP2175; H 93 26; H 9326; Seloken AstraZeneca Brand; Tartrate, Metoprolol; 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-

Networked: 2137 relevant articles (240 outcomes, 570 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Amino Alcohols: 14
    - Propanolamines: 3
      - Phenoxypropanolamines: 1
        Metoprolol: 2137
        metoprolol succinate: 121
        alpha-hydroxymetoprolol: 3
        logroton: 2
        H 87-07: 1
        1'-fluorometoprolol
        3-(4-(1-hydroxy-2-methoxyethyl)phenoxy)-1-(isopropylamino)-2-propanol
        4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid
        H117-04
        O-demethylmetoprolol
- Alcohols: 387
  - Amino Alcohols: 14
    - Propanolamines: 3
      - Metoprolol: 2137
        metoprolol succinate: 121
        alpha-hydroxymetoprolol: 3
        logroton: 2
        H 87-07: 1
        1'-fluorometoprolol
        3-(4-(1-hydroxy-2-methoxyethyl)phenoxy)-1-(isopropylamino)-2-propanol
        4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid
        H117-04
        O-demethylmetoprolol
  - Propanols: 2
    - Propanolamines: 3
      - Metoprolol: 2137
        metoprolol succinate: 121
        alpha-hydroxymetoprolol: 3
        logroton: 2
        H 87-07: 1
        1'-fluorometoprolol
        3-(4-(1-hydroxy-2-methoxyethyl)phenoxy)-1-(isopropylamino)-2-propanol
        4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid
        H117-04
        O-demethylmetoprolol

Experts

1.	Torp-Pedersen, Christian: 19 articles (09/2012 - 06/2002)
2.	Swedberg, Karl: 16 articles (01/2015 - 06/2002)
3.	Metra, Marco: 16 articles (11/2007 - 02/2002)
4.	Cleland, John G F: 14 articles (02/2010 - 06/2002)
5.	Komajda, Michel: 13 articles (01/2015 - 06/2002)
6.	Di Lenarda, Andrea: 11 articles (11/2007 - 06/2002)
7.	Lukas, Mary Ann: 10 articles (05/2009 - 11/2004)
8.	Remme, Willem J: 10 articles (11/2007 - 07/2003)
9.	Poole-Wilson, Philip A: 10 articles (08/2007 - 06/2002)
10.	Ibanez, Borja: 8 articles (11/2014 - 06/2007)

Related Diseases

1.	Hypertension (High Blood Pressure) 05/01/2009 - "Although studies have shown extended release Metoprolol to be a safe and effective treatment in children with established hypertension, to the best of our knowledge, it has not been studied in a pediatric emergency setting." 01/01/2002 - "Betaloc ZOK (50-100 mg) is highly effective in patients with mild to moderate essential hypertension." 06/01/1996 - "Multivariate analysis identified a group of patients with a history of mild hypertension (blood pressure between 140/90 and 170/100 mmHg) and significantly higher probability of improvement with longterm metoprolol (odds ratio [OR], 2.22; 95% confidence interval, 1.25-3.94; P = .007). " 02/01/1990 - "The studies indicate that 50 mg metoprolol CR/ZOK may be an effective antihypertensive agent which may prove useful in the treatment of mild to moderate hypertension, particularly in the elderly." 02/01/2007 - "These data indicate that ER metoprolol is an effective and well-tolerated treatment for hypertension in children."
2.	Heart Failure 06/01/1999 - "Although metoprolol has been proven to be beneficial in the majority of patients with heart failure, a subset of the remaining patients shows long-term survival without satisfactory clinical improvement. " 06/01/1998 - "Dogs treated with metoprolol had a marked decrease in CPT-I activity (0.46 +/- 0.03 vs. 0.64 +/- 0.02 micromol min(-1) g(-1) wet weight; P < .02) along with an increase in triglyceride concentration compared to untreated heart failure dogs (3.9 +/- 0.3 v 4.9 +/- 0.2 micromol/g wet weight, respectively; P < .003). " 02/01/1999 - "Thus, a parallel improvement of myocardial NE reuptake and of hemodynamics was observed after a 6-mo metoprolol therapy, suggesting that such agents may be beneficial in heart failure by directly protecting the myocardium against excessive NE stimulation." 12/01/1993 - "beta-Blockers, especially metoprolol, appear beneficial in some patients with heart failure, possibly related to their reduction in sympathetic nervous activity and restoration of beta-receptor population, with resultant improved contractile performance, enhanced myocardial relaxation, and overall increase in cardiac efficiency. " 06/10/2014 - "In patients with anterior Killip class ≤II STEMI undergoing pPCI, early IV metoprolol before reperfusion resulted in higher long-term LVEF, reduced incidence of severe LV systolic dysfunction and ICD indications, and fewer heart failure admissions. "
3.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 02/01/2001 - "In idiopathic dilated cardiomyopathy, the more significant improvement in symptoms and left ventricular function and size, that is observed following treatment using metoprolol, translates into a better outcome. " 05/01/1994 - "Metoprolol improved hemodynamic status in patients with dilated cardiomyopathy at rest and had a more pronounced effect during exercise. " 12/04/1997 - "Improvement in symptom score was reported in the Metoprolol in Dilated Cardiomyopathy (MDC) trial far patients treated with metoprolol. " 05/01/1993 - "This study thus provides evidence that long-term metoprolol therapy for dilated cardiomyopathy is associated with beta-receptor up-regulation, and the restoration of myocardial beta-receptor density may be associated with the improved cardiac function as determined by echocardiography." 09/01/1985 - "Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: a double-blind, randomized, placebo-controlled trial."
4.	Angina Pectoris 01/01/2006 - "We conclude that metoprolol might exert a significantly greater therapeutic effect on stress-induced angina pectoris in men than in women and this difference should be taken into account when prescribing this beta-blocker." 01/01/1981 - "To assess the duration of improved exercise tolerance by metoprolol given in a new sustained-release formulation, 40 in-patients affected by stable exercise-induced angina pectoris received single-blind placebo in day 1 and thereafter, in double-blind cross-over once daily administration, metoprolol RETARD 100 mg and 200 mg in days 3 and 5. Symptom-limited cycloergometric exercise tests were performed at 3 and 24 hours after placebo and after each of the two doses of metoprolol RETARD. " 01/01/1981 - "These findings indicate that once daily administration of metoprolol Durules is an effective and safe therapy in angina pectoris." 01/01/1981 - "A dose-response study on metoprolol in angina pectoris." 08/01/1976 - "An eighteen months' study of the clinical response to metoprolol, a selective beta1-receptor blocking agent, in patients with angina pectoris."
5.	Migraine Disorders (Migraine) 09/01/2007 - "Metoprolol was proven to be effective in migraine prophylaxis in clinical trials, but its mechanism of action has not been clarified yet. " 09/01/2007 - "After 3 months, a significant reduction of migraine frequency, duration and intensity was demonstrated for the metoprolol compared with the placebo group. " 02/01/1991 - "A significant improvement was noted in 54.4% of patients with migraine during treatment with metoprolol. " 03/01/2001 - "The findings from this trial show that metoprolol is superior to ASA for migraine prophylaxis but has more side-effects. " 11/01/2006 - "In a randomized controlled multicenter trial extending over 24 weeks, we investigated whether acupuncture is as effective and safe as metoprolol in the prophylactic treatment of migraine under conditions similar to routine care. "

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Related Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
2.	Oral Administration
3.	Drug Therapy (Chemotherapy)
4.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
5.	Transplantation (Transplant Recipients)