Methotrexate (Mexate)

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Also Known As:

Mexate; Methotrexate Hydrate; Methotrexate Sodium; Methotrexate, (D)-Isomer; Methotrexate, (DL)-Isomer; Methotrexate, Dicesium Salt; Methotrexate, Disodium Salt; Methotrexate, Sodium Salt; Dicesium Salt Methotrexate; Hydrate, Methotrexate; Sodium, Methotrexate; Amethopterin; L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-

Networked: 24421 relevant articles (2593 outcomes, 3808 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 207
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 149
      - Pterins: 156
        Aminopterin: 244
        Methotrexate: 24421
        CARE protocol: 342
        Regimen B: 125
        methotrexate polyglutamate: 58
        CMF regimen: 42
        CMFVP protocol: 41
        7-hydroxymethotrexate: 38
        PROMACE-CytaBOM protocol: 35
        LSA2-L2 protocol: 30
        M-VAC protocol: 30
        methotrexate-serum albumin: 19
        MDC protocol: 18
        MACOP-B regimen: 15
        ANAVACYM protocol: 13
        AMF protocol: 10
        MACHO protocol: 9
        N-(1-((2,4-diamino-6-pteridinyl)methyl)-3,4-dihydro -2H-1,4-benzothiazine-7-carbonyl)-L-2-aminoadipic acid: 9
        CMF protocol: 8
        fluoresceinated methotrexate: 8
        MBD protocol: 8
        MP regimen: 8
        T7 protocol: 7
        hexa CAF protocol: 6
        BFM 78 protocol: 5
        CMFPT protocol: 5
        HELP protocol: 5
        methotrexate-alpha-phenylalanine: 5
        LMB89 protocol: 4
        MAC combination: 4
        MACOP-B protocol: 4
        3',5'-dichloromethotrexate: 3
        CMF-B protocol: 3
        COMP protocol: 3
        MEA regimen: 3
        methotrexate-gamma-1,2-dimyristoylphosphatidylethanolamine: 3
        New York protocol: 3
        TNP 351: 3
        VBM protocol: 3
        CCG-141 protocol: 2
        CMV regimen: 2
        deoxyaminopteroic acid: 2
        DTPA-methotrexate: 2
        EMA-CO protocol: 2
        fluorescein-methotrexate: 2
        M-BACOD protocol: 2
        MATILDE regimen: 2
        MCC protocol: 2
        methotrexate bisphosphonate: 2
        methotrexate-gamma-aspartate: 2
        MMM protocol 2: 2
        PBMF protocol: 2
        PRIME protocol: 2
        tetrahydromethotrexate: 2
        VMP protocol: 2
        06-Paris-LA-66 protocol: 1
        3'-chloromethotrexate: 1
        5-deazamethotrexate: 1
        AIEOP acute lymphoblastic leukemia protocol: 1
        AWO54: 1
        BCMV protocol: 1
        biotin-SS-methotrexate: 1
        BMFt protocol: 1
        BOMES protocol: 1
        BOP-CISCA-POMB-ACE regimen: 1
        C'MP protocol: 1
        CAM combination: 1
        CAMBO-VIP protocol: 1
        CAMP protocol: 1
        CMED protocol: 1
        CNR-NEO 2 protocol: 1
        COMET-A protocol: 1
        COMPA regimen: 1
        COSS-86 protocol: 1
        EMB protocol: 1
        FEMTX-P protocol: 1
        gamma-tert-butyl methotrexate: 1
        IVAM regimen: 1
        L-6 protocol: 1
        LMV protocol: 1
        LNH87-2 protocol: 1
        M-VEC protocol: 1
        MCNO regimen: 1
        MDACC protocol: 1
        MEC protocol 1: 1
        methotrexate-alpha-alanine: 1
        MFL protocol: 1
        N,N,O,O-tetrakis(tert-butyldimethylsilyl)methotrexate: 1
        NMF protocol: 1
        NSC-98579: 1
        OS 87 protocol: 1
        PHEA-MTX conjugate: 1
        ProMACE-MOPP protocol: 1
        protocol 8001: 1
        SIOP-II protocol: 1
        Stanford University protocol: 1
        T-6 protocol: 1
        T-8801 protocol: 1
        VAMP protocol: 1
        VIM-Bleo protocol: 1
        VPC regimen: 1
        (COMPADRI)-III protocol

Experts

1.	Takeuchi, Tsutomu: 98 articles (12/2023 - 12/2004)
2.	Tanaka, Yoshiya: 87 articles (03/2024 - 12/2002)
3.	Emery, Paul: 85 articles (09/2023 - 02/2002)
4.	Smolen, Josef S: 57 articles (03/2024 - 10/2004)
5.	van der Heijde, Désirée: 54 articles (03/2024 - 01/2003)
6.	Fleischmann, Roy: 53 articles (06/2023 - 01/2002)
7.	Weinblatt, Michael E: 50 articles (08/2023 - 03/2002)
8.	Genovese, Mark C: 49 articles (01/2021 - 06/2002)
9.	Yamanaka, Hisashi: 48 articles (07/2023 - 04/2002)
10.	Curtis, Jeffrey R: 47 articles (01/2024 - 08/2011)

Related Diseases

1.	Rheumatoid Arthritis 01/01/1994 - "Early placebo-controlled trials demonstrated that weekly low dosage methotrexate produced early symptomatic improvement in most rheumatoid arthritis patients. " 01/01/1990 - "In a double-blind, randomized trial of methotrexate vs placebo in rheumatoid arthritis, the effect of treatment on physical, social, and emotional function was measured in two different ways: the same, standard measurements in all patients, and individualized measurements selected by the patients at the start of the trial as representing the functions they most wanted to have improved by treatment. " 02/01/2024 - "Methotrexate (MTX) is the cornerstone of rheumatoid arthritis (RA) treatment and is highly effective with low-dose intermittent administration. " 05/01/2019 - "Methotrexate is the most frequently administered first-line treatment for rheumatoid arthritis (RA). " 04/01/2004 - "(1) There is no consensus on the best treatment option for rheumatoid arthritis when a first-line agent fails (most often methotrexate). "
2.	Neoplasms (Cancer) 10/04/2017 - "Indeed, in the test of using these nanostructures for delivery of a negatively charged anticancer drug, methotrexate (MTX), in a mouse model, dramatically improved therapeutic efficacy is achieved, indicated by the effective inhibition of tumor growth. " 05/15/1987 - "Our results suggest that an analog which could be effectively transported by the low-affinity/high-capacity route may be useful in the treatment of tumors resistant to methotrexate due to a defective high-affinity/low capacity influx system. " 10/01/1975 - "In view of the absence of complications, the regressions in tumor size, and the increase in postoperative disease-free interval in this trial, evaluation as preoperative adjuvants of higher doses of methotrexate and of other chemotherapeutic agents in combination with methotrexate appears warranted." 01/01/2017 - "To amplify the efficacy of magnetically induced thermal treatments, we elucidated the superior tumor-destructive effect of methotrexate-coupled MNPs (MTX/MNPs) in combination with magnetic heating (nanochemothermia) over the thermal treatment alone. " 07/01/1989 - "This preliminary study demonstrates that anal injection of methotrexate is effective in the treatment of advanced cancer. "
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2023 - "As per first line treatment methotrexate is the most widely used cytotoxic drug for psoriasis. " 01/01/2009 - "Methotrexate is the best treatment for severe psoriasis. " 01/01/2006 - "Methotrexate appears to be the most cost-effective agent for the treatment of severe psoriasis. " 10/01/2004 - "Methotrexate 0.25% in a hydrophilic gel is well tolerated but is not very effective in controlling the lesions of psoriasis on the palms and soles. " 01/01/2012 - "Our study concluded to the efficacy of methotrexate in severe psoriasis with a high rate and long term remission, despite lower doses than those classically used in the literature."
4.	Lymphoma (Lymphomas) 09/01/2019 - "Methotrexate (MTX) is used in first-line treatment of primary central nervous system lymphoma (PCNSL), but most cases result in relapse-acquired resistance to MTX. " 01/01/2014 - "Methotrexate (MTX) is the single most effective agent for the treatment of primary central nervous system lymphoma. " 01/01/2008 - "Methotrexate (Mtx) is highly effective in lymphomas and crosses the blood-brain barrier. " 01/01/2022 - "Following six cycles of systemic immunochemotherapy with R-DA-EPOCH, and high methotrexate dose for CNS prophylaxis a marked decrease of lymphoma infiltration was observed. " 08/01/2002 - "Spontaneous complete remission of the lymphoma was achieved 14 months after withdrawing immune suppression with methotrexate."
5.	Ectopic Pregnancy 06/01/2009 - "Medical management with methotrexate is highly effective for properly selected patients with ectopic pregnancy. " 11/01/1999 - "To evaluate the efficacy of a predictive score for the systemic treatment of unruptured ectopic pregnancy with a single dose of methotrexate in order to select the best cases for the medical treatment. " 12/01/2012 - "A case of cervical ectopic pregnancy: successful therapy with methotrexate." 04/01/2007 - "The Authors report two cases of angular live ectopic pregnancies treated successfully with transabdominal injection of Methotrexate." 07/01/2006 - "We report the cases of 2 adolescents with ectopic pregnancies who were treated successfully with methotrexate."

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4.	Fluorouracil (Carac)
5.	Cisplatin (Platino)
6.	Vincristine (Oncovin)
7.	Antirheumatic Agents (DMARD)
8.	Etanercept (Enbrel)
9.	Adrenal Cortex Hormones (Corticosteroids)
10.	Infliximab (Remicade)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Combination Drug Therapy (Combination Chemotherapy)
5.	Remission Induction