AWO54

prodrug ofMTX bis(dodecylamide); structure in first source

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

1.	Arthritis (Polyarthritis) 08/01/2008 - "The efficacy of the drug was tested in two different stages of CIA: while both, MTX and AWO54 inhibited arthritis in an early stage of the disease, in a later stage only AWO54 showed a significant inhibitory effect in comparison with control. "
2.	Inflammation (Inflammations) 08/01/2008 - "The prodrug AWO54 with the formula EMC-d-Ala-Phe-Lys-Lys-MTX binds selectively to the cysteine-34 position of endogenous albumin, which acts as a macromolecular drug carrier for MTX to the site of inflammation. "
3.	Rheumatoid Arthritis 08/01/2008 - "The albumin-bound form of AWO54 was efficiently cleaved by cathepsin B and plasmin, two proteases that are overexpressed in rheumatoid arthritis, and release a MTX lysine derivative. "

1.	Prodrugs
2.	Peptide Hydrolases (Proteases)
3.	Lysine (L-Lysine)
4.	Fibrinolysin
5.	Drug Carriers
6.	Cathepsin B
7.	Albumins
8.	lysyllysine (Lys-Lys)
9.	alanylphenylalanine (Ala-Phe)