Lignin

The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)

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Networked: 162 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sakagami, Hiroshi: 3 articles (01/2014 - 07/2008)
2.	Stewart, C Neal: 2 articles (09/2014 - 11/2013)
3.	Wang, Zeng-Yu: 2 articles (09/2014 - 11/2013)
4.	Mazarei, Mitra: 2 articles (09/2014 - 11/2013)
5.	Fu, Chunxiang: 2 articles (09/2014 - 11/2013)
6.	Dixon, Richard A: 2 articles (09/2014 - 11/2013)
7.	Chapple, Clint: 2 articles (02/2014 - 12/2010)
8.	Thakkar, Jay N: 2 articles (04/2013 - 05/2010)
9.	Desai, Umesh R: 2 articles (04/2013 - 05/2010)
10.	Sun, Run-Cang: 2 articles (07/2012 - 06/2011)

Related Diseases

1.	Gallstones (Gallstone) 12/01/1981 - "Animals fed lignin had significantly fewer gallstones (11 of 25), improved cholesterol saturation of gallbladder bile, and increased fecal bile acid excretion. " 12/01/1981 - "Lignin appears to prevent cholesterol gallstones in this model by improving cholesterol saturation of bile. " 12/01/1981 - "Gallstones were completely prevented in animals fed both lignin and lactulose (0 of 22), but gallbladder bile cholesterol saturation was not significantly different from the lignin-fed group. " 12/01/1981 - "The effect on prevention of cholesterol gallstones by a nonfermentable type of fiber, lignin, and a fermentable fiber analogue, lactulose, was studied in hamsters fed an essential fatty acid deficient diet. " 12/01/1981 - "Prevention of cholesterol gallstones by lignin and lactulose in the hamster."
2.	HIV Infections (HIV Infection) 11/01/1992 - "HIV infection caused significant reduction of MPO activity in HL-60 cells, regardless of the presence or absence of lignins. " 01/01/2014 - "Lignin-carbohydrate complex protected the cells from the cytopathic effects of HIV infection and UV irradiation more efficiently than other polyphenols. " 07/01/2008 - "SE protected human T-cell leukemia MT-4 cells from the cytopathic effect of human immunodeficiency virus (HIV) infection, and its anti-HIV activity was much higher than that of tannins and flavonoids, comparable with that of natural and synthetic lignins. "
3.	Acquired Immunodeficiency Syndrome (AIDS) 08/01/1992 - "These results suggest that lignin structure, regardless of whether synthetic or natural, may inhibit HIV replication by an unidentified process, and thus prove to be a new class of anti-HIV agents possibly effective in the treatment of AIDS (acquired immunodeficiency syndrome)." 03/01/2008 - "Low molecular lignin may be a beneficial material or drug leads as a new class for AIDS and NF-kappaB-related diseases."
4.	Neoplasms (Cancer) 01/01/1997 - "Dietary lignin did not significantly affect colon tumor incidence or multiplicity compared with the fiber-free diet. " 08/01/1995 - "Our results on the presence of specific lignin fractions in high-risk food items that can induce important cellular functions linked to tumor promotion are discussed in relation to NPC genesis and etiology." 03/01/1992 - "Differential responses of lignin derivatives between tumor and normal tissue derived cell lines; effects on cellular adhesion and cell growth." 06/01/1990 - "Morphological changes of tumor cells caused by macrophages treated with lignin derivatives." 03/01/1992 - "The present study revealed that the lignin derivatives demonstrated differential responses between cells derived from tumor tissues and from normal tissues, and that the lignin derivatives strongly inhibited the growth of mouse sarcoma cells (FRUKTO) and rat foetal cells (Ad12-3Y1-Z19) transformed with adeno virus type 12."
5.	Body Weight (Weight, Body) 04/01/2008 - "The study aimed to investigate the effects of insoluble dietary fibre differing in lignin content on performance and parameters of gut microbiology in 48 weanling piglets (8.5 kg mean body weight) fed common diets ad libitum. " 01/01/1998 - "Dietary lignin and MNU treatment increased food consumption (p < 0.05), and body weight was slightly reduced at 10 and 20 weeks after MNU in the MNU-5% lignin diet group (p < 0.05). " 05/01/1988 - "A 5 X 5 Latin square design involving five cannulated beef steers (342 and 358 kg avg initial and final body weights, respectively) fed prairie hay (76.7% neutral detergent fiber, 5.7% acid detergent lignin and .85% N) was conducted to evaluate effects on feed intake and nutrient digestion of variations in physical characteristics of ruminal digesta achieved by ruminal insertion of different amounts of prairie hay differing in particle size. "

Related Drugs and Biologics

1.	Cholesterol
2.	Anti-HIV Agents (AIDS Drugs)
3.	Cellulose
4.	Flavonoids
5.	pectin
6.	Chitosan
7.	Lignans
8.	Biofuels
9.	Chalcones
10.	Xanthones

Related Therapies and Procedures

1.	Bioreactors