Isoflurane

01/01/2015 - "Preconditioning with the volatile anesthetic isoflurane exerts protective effects in animal models of ischemia. "
01/01/2013 - "This study investigates isoflurane-induced protection against ischemia of skin flap and the underlying molecular mechanism in this process. "
01/01/2011 - "The results suggest that isoflurane preconditioning induces endothelial protection against in-vitro simulated ischemia. "
12/01/2007 - "Isoflurane also improved the motor coordination of rats at 1 month after ischemia. "
07/01/2006 - "Isoflurane provides protection against severe forebrain ischemia in the rat. "

12/01/2011 - "Isoflurane has demonstrated protective effects against ischemia/reperfusion injury in some organs. "
10/01/2015 - "Isoflurane decreased infarct size from 54 ± 10% in control to 36 ± 10% (P < 0.05, n = 8 mice per group), improved cardiac function after reperfusion, and increased the ratios of phosphorylated-Akt/AKT, phosphorylated-eNOS/eNOS, and phosphorylated-nNOS/nNOS in C57BL/6 mice subjected to ischemia-reperfusion injury. "
01/01/2014 - "Isoflurane preconditioning ameliorates renal ischemia-reperfusion injury through antiinflammatory and antiapoptotic actions in rats."
06/20/2011 - "Pre-treatment with isoflurane ameliorates renal ischemic-reperfusion injury in mice."
05/01/2008 - "Our results indicate that, in rabbits, i.v. emulsified isoflurane provides similar myocardial protection against ischemia-reperfusion injury as inhaled isoflurane."

08/07/2002 - "Three hours of exposure to 1% isoflurane induced rapid and longlasting protection against 60 min transient focal cerebral ischemia induced by filament occlusion of the middle cerebral artery (MCAO). "
06/01/2013 - "Our results suggest that isoflurane postconditioning improved long-term neurological outcome after transient focal brain ischemia. "
05/01/2010 - "Our data demonstrate that isoflurane pretreatment improved rCBF and increased the regional O(2) supply and consumption in the focal ischemic area but did not affect capillary permeability during the early stage of focal cerebral ischemia. "
12/01/2009 - "Isoflurane preconditioning improved short-term neurological outcome after focal brain ischemia in adult rats. "
06/01/2008 - "Application of isoflurane during reperfusion also improved neurologic outcome after brain ischemia. "

09/01/1986 - "It is concluded that isoflurane is a safe and effective agent for the induction of hypotension in neurosurgical operations."
05/01/2010 - "Impedance threshold device in dogs during isoflurane-induced hypotension improved CI and SAP but had negative effects on RC and ResR."
11/01/2003 - "Isoflurane resulted in improved neurologic function and reduced histologic damage regardless of the presence or absence of systemic hypotension during the ischemic insult. "
11/01/2003 - "This study was designed to determine if isoflurane protection persists in a global insult devoid of hypotension. "
05/01/1997 - "The present study demonstrates that isoflurane produces similar effects on systemic blood pressure, regional cerebral blood flow and sympathetic efferent discharge during vasodilator-induced hypotension and without any vasodilator."

01/01/2012 - "Isoflurane preconditioning and hypoxia preconditioning significantly reduced infarct volume and improved neurological outcome in wild-type and SPK1(-/-) mice but not in SPK2(-/-) mice. "
03/01/2008 - "Because a rapid rebound response did not develop, inhalation of NO might be clinically useful in the treatment of hypoxemia in healthy isoflurane-anesthetized horses."
02/10/1987 - "Isoflurane (1.5%) was able to provide a small degree of protection against shorter periods (7 min) of anoxia."
01/01/2012 - "In this study we investigated the effect of a 2-hour isoflurane exposure on apoptosis of the cerebral endothelium following 24 hours of hypoxia in an in vitro BBB model using astrocyte-conditioned human umbilical vein endothelial cells (AC-HUVECs). "
04/01/2000 - "This study examined how a period of global birth anoxia and isoflurane/N2O anaesthesia interact to affect measures of CNS and systemic hypoxia in neonatal rats born by C-section compared with control, vaginally born animals. "