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Propofol (Diprivan)

An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.

Also Known As:

Diprivan; 2,6-Bis(1-methylethyl)phenol; 2,6-Diisopropylphenol; Abbott Brand of Propofol; Alpha Brand of Propofol; Aquafol; Astra Brand of Propofol; AstraZeneca Brand of Propofol; Braun Brand of Propofol; Curamed Brand of Propofol; Disoprivan; Fresenius Brand of Propofol; Fresenius Kabi Brand of Propofol; Fresofol; ICI-35,868; ICI-35868; Ivofol; Juste Brand of Propofol; Parnell Brand of Propofol; Pisa Brand of Propofol; Propofol Abbott; Propofol Fresenius; Propofol MCT; Propofol Rovi; Propofol-Lipuro; Recofol; Rovi Brand of Propofol; Schering Brand of Propofol; Zeneca Brand of Propofol; 2,6 Diisopropylphenol; ICI 35,868; ICI 35868; ICI35,868; ICI35868; Disoprofol; Phenol, 2,6-bis(1-methylethyl)-

Networked: 4729 relevant articles (420 outcomes, 784 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Phenols: 309
  - Propofol: 4729

Experts

1.	Fujii, Yoshitaka: 29 articles (12/2011 - 01/2002)
2.	Xia, Zhengyuan: 13 articles (01/2015 - 01/2003)
3.	Shingu, Koh: 11 articles (07/2015 - 01/2002)
4.	Saito, Shigeru: 11 articles (06/2015 - 05/2002)
5.	Sessler, Daniel I: 9 articles (03/2015 - 01/2005)
6.	Fujii, Y: 9 articles (07/2011 - 06/2000)
7.	Inada, Takefumi: 8 articles (07/2015 - 01/2007)
8.	Irwin, Michael G: 8 articles (01/2015 - 09/2005)
9.	Brown, Emery N: 8 articles (12/2014 - 01/2009)
10.	Laureys, Steven: 8 articles (01/2014 - 11/2010)

Related Diseases

1.	Pain (Aches) 12/01/2009 - "Our objective in this randomized, double-blind, placebo-controlled trial was to determine whether a single IV dose of propofol 2.4 mg/kg results in clinically significant reduction in disability or pain in CDH for the next 30 days. " 04/01/2014 - "There was a significant reduction in propofol induced pain score P = 0.0275 and insignificant hemodynamic changes. " 11/01/2011 - "To compare the clinical efficacy of a rapid injection of propofol in regard to pain and ability to facilitate Laryngeal Mask Airway (LMA) insertion. " 03/01/2000 - "The intensity of injection pain was significantly greater for pure propofol than the others while it was not significantly different among the other groups in comparison. " 09/01/1996 - "Propofol at the two higher doses during part of the first immersion produced a significant reduction (p < 0.05) in pain intensity and bothersomeness ratings. "
2.	Postoperative Nausea and Vomiting (PONV) 06/01/1999 - "Propofol is effective in managing PONV with shorter PACU stay and great degree of patient satisfaction. " 11/01/1996 - "Propofol used only as an induction agent or for induction and at the end of surgery were not as protective against postoperative nausea and vomiting." 06/01/1999 - "This study determines the efficacy of small doses of propofol administered by patient-controlled device for the treatment of PONV. " 08/01/1998 - "Lack of efficacy of propofol in the treatment of early postoperative nausea and vomiting." 07/01/2013 - "The study found that the PONV was significantly reduced in the patient with propofol, no hemodynamic derangements were noted in the postoperative period."
3.	Vomiting 04/01/1997 - "To investigate the efficacy of a subhypnotic dose of propofol to treat vomiting in children after adenotonsillectomy. " 08/01/2011 - "The intravenous anesthetic propofol has a number of well-known nonanesthetic effects, including anti-oxidation and anti-emesis. " 08/01/2010 - "There were no reported incidents of aspiration or emesis during sedation and there were no deaths associated with procedural propofol sedation. " 01/01/2009 - "The 0.257 absolute risk reduction of vomiting with the addition of propofol represents a number needed to treat of 3.87, and a risk ratio of 0.51 (95% CI 0.32 to 0.79). " 10/01/2007 - "To evaluate the rate of adverse respiratory events and vomiting among ED patients undergoing procedural sedation with propofol. "
4.	Seizures (Seizure) 04/01/1999 - "We observed that propofol was very effective for the refractory general convulsion after surgical operation of cerebral aneurysmal clipping in two patients. " 03/01/2008 - "The present results showed that there was significant reduction in the time required for onset of seizure in propofol treated groups following PTZ treatment. " 09/01/2014 - "Herein, the author reviews the extensive literature for propofol in ECT, focusing on 5 outcome measures: seizure duration, hemodynamics, postanesthesia recovery, cognitive adverse effects, and therapeutic efficacy. " 12/01/2004 - "Propofol proved to be effective in preventing agitation when used as induction agent or when administered at seizure end. " 08/01/1992 - "The greater efficacy of propofol against PTZ convulsions may be a reflection of the opposite action of the two drugs on neural membrane conductance: PTZ induces paroxysmal neural discharge by enhancing membrane conductance while propofol appears to decrease membrane conductance, thus suppressing paroxysmal discharge. "
5.	Nausea 09/01/2003 - "Moreover, propofol at a subhypnotic dose is effective in the prevention of severe nausea." 03/01/2014 - "The incidence of nausea significantly lower in the propofol 0.5 and propofol 1.0 groups than in the control group (12.1 vs 14.7 vs 40%). " 11/01/2003 - "The propofol infusion group experienced significantly more nausea in the recovery room (p = 0.002), nausea at the time of discharge (p = 0.009), and nausea the evening after the operation (p = 0.013). " 03/01/2001 - "Nausea was less frequent after propofol (16% vs. 48%, P<0.05). " 05/01/1999 - "One patient (3%) experienced nausea prior to discharge in the propofol-N2O group, and two patients (6%) experienced nausea at home in the propofol alone group. "

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4.	Ketamine
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6.	Thiopental (Pentothal)
7.	sevoflurane (Ultane)
8.	Ondansetron (Zofran)
9.	Metoclopramide (Reglan)
10.	Dexamethasone (Maxidex)

Related Therapies and Procedures

1.	Anesthesia
2.	Tourniquets
3.	Intravenous Anesthesia
4.	Analgesia
5.	General Anesthesia